Leukocyte gene expression signatures in antineutrophil cytoplasmic autoantibody and lupus glomerulonephritis (original) (raw)

Leukocytes are pivotal in autoimmune disease progression, and this study explores gene expression variations in leukocytes from patients with antineutrophil cytoplasmic autoantibody (ANCA), systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA) compared to healthy donors. Utilizing Affymetrix U133A/B chips, distinct gene signatures were identified that correlated with clinical activity levels in ANCA patients. The findings suggest that specific gene expression profiles in leukocyte subtypes could help in monitoring and quantifying disease activity, offering potential pathways for targeted clinical interventions.