An M1 selective agonist AF102b, as a potential drug in treatment of Alzheimer's disease: Biochemical and pharmacological properties (original) (raw)

Cytoskeletal and Phosphoinositide Requirements for Muscarinic Receptor Signaling to Focal Adhesion Kinase and Paxillin

Journal of Neurochemistry, 2002

Regulation of Cellular Tyrosine Phosphorylation by Stimulatory and Inhibitory Muscarinic Acetylcholine Receptors

Experimental Cell Research, 1997

Stimulation of M3 Muscarinic Receptors Induces Phosphorylation of the Cdc42 Effector Activated Cdc42Hs-associated Kinase-1 via a Fyn Tyrosine Kinase Signaling Pathway

Kim Heidenreich

Journal of Biological Chemistry, 2001

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Differential coupling of muscarinic receptors to Ca2+ mobilization and cyclic AMP in SH-SY5Y and IMR 32 neuroblastoma cells

jari heikkila

European Journal of Pharmacology: Molecular Pharmacology, 1991

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Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking

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Molecular Biology of the Cell, 1995

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Cholecystokinin-stimulated tyrosine phosphorylation of p125(FAK) and paxillin is mediated by phospholipase C-dependent and -independent mechanisms and requires the integrity of the actin cytoskeleton and participation of p21(rho)

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Journal of Biological Chemistry, 1996

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Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-γ: An alternative mechanism for cholinergic-induced phosphoinositide breakdown

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Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation

Martina Schmidt

European Journal of Biochemistry, 1994

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Cytosolic phospholipase A2 is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: characterization of the transducing mechanism

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Modulation of phosphatidylserine synthesis by a muscarinic receptor occupancy in human neuroblastoma cell line LA-N-1

Raphael Massarelli

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Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor

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American Journal of Physiology-Cell Physiology, 2006

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Location of agonist-dependent-phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype)

T. Haga

European Journal of Biochemistry, 1994

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Muscarinic receptors, phosphoinositide metabolism and intracellular calcium in neuronal cells

Emma Whitham

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1992

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Reduction of Aβ accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidylinositol kinase inhibitor wortmannin

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Relationship between agonist binding, phosphorylation and immunoprecipitation of the m3-muscarinic receptor, and second messenger responses

Gary Willars

British Journal of Pharmacology, 1995

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Muscarinic receptor-induced phosphoinositide hydrolysis at resting cytosolic Ca2+ concentration in PC12 cells

Lucia Vicentini

The Journal of Cell Biology, 1985

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Muscarinic receptor-linked elevation of cAMP in SH-SY5Y neuroblastoma cells is mediated by Ca2+ and protein kinase C

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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1991

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Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1

Gabriel Berstein

Journal of Biological Chemistry, 1992

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Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

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… and cellular biology, 1996

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Reduction of A accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidylinositol kinase inhibitor wortmannin

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Characterization of a Soluble Adrenal Phosphatidylinositol 4-Kinase Reveals Wortmannin Sensitivity of Type III Phosphatidylinositol Kinases †

Gregory Downing

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Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3-kinase inhibitor, wortmannin

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Quantitative comparisons of muscarinic and bradykinin receptor-mediated Ins (1,4,5)P3 accumulation and Ca2+ signalling in human neuroblastoma cells

Gary Willars

British Journal of Pharmacology, 1995

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Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by muscarinic agonists

Pedro R. Barreno

Biochemical Journal, 1989

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Involvement of Protein Kinase C and Protein Kinase A in the Muscarinic Receptor Signalling Pathways Mediating Phospholipase C Activation, Arachidonic Acid Release and Calcium Mobilisation

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Evidence that a Guanine Nucleotide-Binding Protein Linked to a Muscarinic Receptor Inhibits Directly Phospholipase C

Maria Di Girolamo

Proceedings of The National Academy of Sciences, 1990

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Phosphorylation of muscarinic receptors: regulation by G proteins

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Phospholipid metabolism is required for M1 muscarinic inhibition of N-type calcium current in sympathetic neurons

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Activation of second messenger-dependent protein kinases induces muscarinic acetylcholine receptor desensitization in rat thyroid epithelial cells

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Molecular and Cellular Endocrinology, 2004

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Muscarinic activation of mitogen-activated protein kinase in rat thyroid epithelial cells

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ADP-ribosylation Factor-dependent Phospholipase D Activation by the M3 Muscarinic Receptor

Derek Robertson

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Stimulation of receptor protein-tyrosine phosphatase alpha activity and phosphorylation by phorbol ester

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Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 1995

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Effects of alkylating antagonists on the stimulated turnover of phosphatidylinositol produced by a variety of calcium-mobilising receptor systems

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Cell Calcium, 1980

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An M1 selective agonist AF102b, as a potential drug in treatment of Alzheimer's disease: Biochemical and pharmacological properties (original) (raw)

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