Disparity in circulating adiponectin multimers between term and preterm infants (original) (raw)
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Circulating levels of adiponectin in preterm infants
Archives of Disease in Childhood - Fetal and Neonatal Edition, 2007
Objective: To determine circulating levels of adiponectin in preterm infants and examine possible associations with anthropometric measurements, weight gain, and leptin and insulin levels. Design: Prospective study. Setting: A university hospital neonatal care unit. Study population: 62 preterm (mean (SD) gestational age 32.0 (2.1) weeks) and 15 full-term infants (reference group).
Correlations between umbilical and maternal serum adiponectin levels and neonatal birthweights
Acta Obstetricia Et Gynecologica Scandinavica, 2004
Objective. To measure adiponectin levels in maternal serum and umbilical cord serum at delivery, and examine whether or not there are correlations between adiponectin levels and neonatal birthweights, maternal body weights and body mass indexes. Study design. The study included 84 healthy mothers who had given birth to healthy neonates. Adiponectin levels in maternal serum and umbilical cord serum were determined by radioimmunoassay and compared.
Preterm and Term Newborns Serum Adiponectin and Leptin Concentrations Maced
2020
Introduction: Serum adipocytokines concentration, their mutual relationship and correlations with anthropometric data could be indicators of fetal and neonatal growth maturity level in term and preterm infants. Objectives: Study was designed to assess the correlation of the anthropometric parameters with leptin and adiponectin levels in healthy preterm and term newborns. Design and Methods: A cohort of 110 neonates of both sexes, born pre term (PT) (n=36) or at term (AT) (n=74), additionally classified as AT-AGA (n=36), AT-SGA (n=18), AT-LGA (n=20) and PT-AGA (n=24), PT-SGA (n=12), according to the Lubchenco curves Mother Body Mass Index-MBMI, Birth Weight-BW, Birth Length-BL, Body Weight/Body Length ratio-BW/BL, Body Mass Index-BMI, Ponderal Index-PI, was recorded after birth. Results: Sex has no influence on mean serum leptin and adiponectin level. However, differences between AT and PT groups were highly (p<0.01) significant (2.20 ± 1.02; 30.77 ± 22.64 and 1.24 ± 0.35; 9.44 ± 4.82 ng/mL, respectively). Significant difference was found in adiponectin levels between AT-AGA and AT-LGA compared to AT-SGA subgroup (32.8 ± 25.41 and 43.40 ± 16.98 vs 12.67 ± 2.45 ng/ mL, respectively, (p<0.01; p<0.01). There was a significant difference between leptin levels (1.93 ± 0.70; 1.71 ± 0.53 vs 3.12 ± 1.27 ng/mL) in AT-AGA and AT-SGA compared to AT-LGA newborns, respectively, (p<0.01; p<0.01). No significant differences were found in leptin and adiponectin levels neather between PT subgroups (1.30 ± 0.38 ng/mL) nor between PT group and AT-SGA (1.71 ± 0.53 ng/mL) subgroup. Leptin and adiponectin levels were positively correlated with all anthropometric parameters: BW, BL, BW/BL, BMI, and PI (p<0.05). Conclusion: These results indicate that the stage of body growth maturity is positively correlated to adipocytokines involved in fetal growth regulation.
Macedonian Journal of Medical Sciences, 2012
Introduction: Serum adipocytokines concentration, their mutual relationship and correlations with anthropometric data could be indicators of fetal and neonatal growth maturity level in term and preterm infants. Objectives: Study was designed to assess the correlation of the anthropometric parameters with leptin and adiponectin levels in healthy preterm and term newborns. Design and Methods: A cohort of 110 neonates of both sexes, born pre term (PT) (n=36) or at term (AT) (n=74), additionally classified as AT-AGA (n=36), AT-SGA (n=18), AT-LGA (n=20) and PT-AGA (n=24), PT-SGA (n=12), according to the Lubchenco curves Mother Body Mass Index-MBMI, Birth Weight-BW, Birth Length-BL, Body Weight/Body Length ratio-BW/BL, Body Mass Index-BMI, Ponderal Index-PI, was recorded after birth. Results: Sex has no influence on mean serum leptin and adiponectin level. However, differences between AT and PT groups were highly (p<0.01) significant (2.20±1.02; 30.77±22.64 and 1.24±0.35; 9.44±4.82 ng/mL, respectively). Significant difference was found in adiponectin levels between AT-AGA and AT-LGA compared to AT-SGA subgroup (32.8±25.41 and 43.40±16.98 vs 12.67±2.45 ng/mL, respectively, (p<0.01; p<0.01). There was a significant difference between leptin levels (1.93±0.70; 1.71±0.53 vs 3.12±1.27 ng/mL) in AT-AGA and AT-SGA compared to AT-LGA newborns, respectively, (p<0.01; p<0.01). No significant differences were found in leptin and adiponectin levels neather between PT subgroups (1.30±0.38 ng/mL) nor between PT group and AT-SGA (1.71±0.53 ng/mL) subgroup. Leptin and adiponectin levels were positively correlated with all anthropometric parameters: BW, BL, BW/BL, BMI, and PI (p<0.05). Conclusion: These results indicate that the stage of body growth maturity is positively correlated to adipocytokines involved in fetal growth regulation.
European Journal of Endocrinology, 2007
A Klamer and K Skogstrand contributed equally to this work Abstract Objective: Adiponectin levels measured in neonatal dried blood spot samples (DBSS) might be affected by both prematurity and being born small for gestational age (SGA). The aim of the study was to measure adiponectin levels in routinely collected neonatal DBSS taken on day 5 (range 3-12) postnatal from infants. Design: A retrospective case-control study. Subjects and methods: One hundred and twenty-two infants: 62 very premature (34 SGA) and 60 mature infants (27 SGA). Adiponectin concentrations were determined in stored neonatal DBSS using a sandwich immunoassay based on flow metric Luminex xMap technology. Results: Adiponectin was measurable in all samples, and repeated measurements correlated significantly (rZ0.94). Adiponectin concentrations were negatively associated with both SGA (BZK0.283, PZ0.04) and prematurity (BZK2.194, P!0.001), independently of each other. In the premature but not the mature group, adiponectin levels increased with increasing postnatal age at blood sampling (BZ0.175, P!0.001). Conclusions: Reliable quantification of adiponectin in stored DBSS is feasible and may be used to study large populations of routinely collected samples. Low levels of adiponectin in neonatal DBSS are associated with SGA as well as prematurity. Blood adiponectin levels increase with postnatal age in premature infants, suggesting a rapid yet unexplained metabolic adaptation to premature extrauterine life.
Maternal serum adiponectin multimers in patients with a small-for-gestational-age newborn
Journal of Perinatal Medicine, 2000
Objective: Several mechanisms of disease have been implicated in the pathophysiology of small-for-gestational-age (SGA) including an anti-angiogenic state, and an exaggerated intravascular pro-inflammatory response. Adiponectin plays a role in a wide range of biological activities including those that have been implicated in the pathophysiology SGA. Thus, the aim of this study was to determine if third trimester adiponectin concentrations differed between women with normal weight infants and those with an SGA neonate. Study design: This cross-sectional study included women with: 1) a normal pregnancy (ns234); and 2) an SGA neonate (ns78). SGA was defined as a birth weight below the 10 th percentile for gestational age at birth. The study population was further stratified by first trimester body mass index (BMI) (normal weight -25 kg/m 2 vs. overweight/obese G25 kg/m 2 ). Maternal serum adiponectin multimers wtotal, high-molecular-weight (HMW), medium-molecular-weight (MMW) and low-molecularweight (LMW)x concentrations were determined by ELISA. Non-parametric statistics were used for analyses. Results: 1) The median maternal serum concentrations of total, HMW and MMW adiponectin were significantly lower in patients with an SGA neonate than in those with normal pregnancies; 2) patients with an SGA neonate had a significantly lower median HMW/total adiponectin ratio and higher median MMW/total adiponectin and LMW/total adiponectin ratios than those with a normal pregnancy; 3) among patients with an SGA neonate, neither maternal serum concentrations of adiponectin multimers, nor their relative distribution differ between normal weight and overweight/obese patients. Conclusion: 1) Pregnancies complicated by an SGA neonate are characterized by a alterations in the maternal serum adiponectin multimers concentrations and their relative abundance; 2) the findings reported herein suggest that maternal adipose tissue may play a role, in the pathogenesis of SGA.
The Journal of clinical endocrinology and metabolism, 2015
Adiponectin enhances insulin sensitivity and may play a role in fetal and postnatal growth. To determine if early postnatal adiponectin concentration change is related to postnatal growth in very preterm infants. In-hospital, prospective, longitudinal cohort study. 52 preterm infants with a gestational age (GA) of 26.0 ± 1.9 (SD) weeks and birth weight (BW) of 889 ± 284 g. Analysis of adiponectin was performed on cord blood at birth and peripheral blood at 72 h, day 7, and then weekly until postmenstrual age (PMA) 40 weeks. Weight, length, and head circumference (HC) measurement was performed weekly and standard deviation scores (SDS) calculated. Energy and protein intake was calculated daily from birth until PMA 35 weeks. Mean adiponectin concentration increased from 6.8 ± 4.4 μg/mL at 72 h to 37.4 ± 22.2 μg/mL at 3 weeks; during days 3-21, it was 21.4 ± 12 μg/mL and correlated with GA at birth (r = 0.46, P = .001; BW: r = 0.71, P < .001; BWSDS: r = 0.42, P = .003). Furthermore,...
Serum adiponectin concentrations in relation to maternaland perinatal characteristics in newborns
European Journal of Endocrinology, 2004
Objective: To assess serum adiponectin levels of neonates in relation to ponderal index and birth length with and without adjustment for potential confounding factors including maternal factors and perinatal characteristics. Design: A cross-sectional study. Methods: Three hundred and three newborns (Caucasian, singleton, full term, with a birth weight of $ 2500 g, and apparently healthy) were included in the study. Blood samples were collected from the newborns no later than the fifth day of life for measurements of adiponectin and major IGF system components (IGF-I, IGF-II, IGF binding protein-3 (IGFBP-3)). The data were analyzed using simple and multiple regression analyses. Results: Adiponectin is substantially higher in neonates than in adults, with no evidence of the gender dimorphism observed among adults. We found an inverse association between neonatal adiponectin levels and newborn ponderal index and a positive association with newborn length by univariate analysis. We also found a statistically significant inverse association of adiponectin with jaundice/bilirubin, and a marginally significant positive association of this hormone with IGFBP-3 but no significant association with any maternal factors. In multivariate analysis, the inverse association between serum adiponectin and ponderal index does not remain significant after adjustment for potential confounding factors. In contrast, neonatal adiponectin levels correlate inversely significantly and independently with liver maturity and IGF-II and tend to remain positively associated with IGFBP-3 and increased birth length. Conclusions: An inverse association of adiponectin with ponderal index by univariate analysis is not independent from confounding factors. In contrast, the positive association between serum adiponectin and birth length may reflect either a direct effect of adiponectin or an adiponectin-mediated increase in the sensitivity of tissues to insulin and components of the IGF system, and needs to be explored further.
Cord blood adiponectin in large-for-gestational age newborns
American Journal of Obstetrics and Gynecology, 2005
Adiponectin Leptin LGA Macrosomia Fetal growth Objective: The purpose of this study was to disclose the relationship between adiponectin and birth weight in a large group of newborns with normal and aberrant growth (''overweight''). Study design: Eighty-one healthy, term newborns were divided into 2 groups: 20 in the large-forgestational age (LGA; 4297 G 207 g), and 61 newborns in the appropriate-for-gestational age (AGA; 3384 G 368 g). Cord blood was analyzed for adiponectin, leptin, and insulin levels. Results: Mean adiponectin level was significantly lower in LGA newborns (29.4 G 13.8 vs 35.0 G 9.9 mg/mL, P ! .04). Both leptin and insulin levels were higher in LGA than AGA newborns, and leptin levels positively correlated with birth weight in both groups. Insulin levels positively correlated with birth weight in AGA newborns. Conclusion: The results of this study imply that adiponectin may have a role in fetal growth and support the notion of negative feedback exerted by adipose tissue on adiponectin levels, as previously shown in adults.
Early Human Development, 2014
Background: Preterm infants have altered fat tissue development, including a higher percentage of fat mass and increased volume of visceral fat. They also have altered adiponectin levels, including a lower ratio of highmolecular-weight adiponectin (HMW-Ad) to total adiponectin (T-Ad) at term-equivalent age, compared with term infants. Aims: The objective of this study was to investigate the association between adiponectin levels and fat tissue accumulation or distribution in preterm infants at term-equivalent age. Study design: Cross-sectional clinical study. Subjects: Study subjects were 53 preterm infants born at ≤ 34 weeks gestation with a mean birth weight of 1592 g. Outcome measures: Serum levels of T-Ad and HMW-Ad were measured and a computed tomography (CT) scan was performed at the level of the umbilicus at term-equivalent age to analyze how fat tissue accumulation or distribution was correlated with adiponectin levels. Results: T-Ad (r = 0.315, p = 0.022) and HMW-Ad levels (r = 0.338, p = 0.013) were positively associated with subcutaneous fat area evaluated by performing CT scan at term-equivalent age, but were not associated with visceral fat area in simple regression analyses. In addition, T-Ad (β = 0.487, p = 0.003) and HMW-Ad levels (β = 0.602, p b 0.001) were positively associated with subcutaneous fat tissue area, but they were not associated with visceral fat area also in multiple regression analyses. Conclusion: Subcutaneous fat accumulation contributes to increased levels of T-Ad and HMW-Ad, while visceral fat accumulation does not influence adiponectin levels in preterm infants at term-equivalent age.