The role of MTNR1B genetic polymorphisms in type 2 diabetes mellitus (original) (raw)

AI-generated Abstract

Background: Type 2 diabetes (T2DM) is a prevalent metabolic disorder influenced by genetic and environmental factors. The molecular mechanisms, particularly in diverse populations, remain inadequately understood. In this study, genetic polymorphisms in the melatonin receptor gene (MTNR1B) were investigated within a Saudi Arabian cohort. Methods: A cohort of 200 T2DM samples was analyzed for mutations or SNPs in the MTNR1B gene using PCR-sequencing. Results: No mutations were identified; however, SNP rs60474139 appeared at 13.5% frequency with no significant association to HbA1c levels. Similarly, SNP rs10830962 showed no significant link to HbA1c levels despite prior associations. Conclusions: Results indicate a limited role for MTNR1B genetic variants in T2DM among the Saudi population, warranting further exploration of epigenetic mechanisms and other circadian genes.