The InsP3 receptor and intracellular Ca2+ signaling (original) (raw)

1997, Current Opinion in Neurobiology

The inositol 1,4,5trisphosphate receptor (InsPsR) is a ligand-gated Ca2+-release channel on intracellular Ca*+ store sites (such as the endoplasmic reticulum), and plays an important role in intracellular Ca*+ signaling in a wide variety of cell types. Recent studies have shown that binding of inositol 1,4,5-trisphosphate (InsPs) to lnsPsR isoforms is differentially regulated by Ca*+, and that InsPsR functions are finely regulated by phosphorylation via tyrosine kinases and protein kinase C, by dephosphorylation via calcineurin, and by binding to FKBP (FK506-binding protein). In addition, transient receptor potential (TRP) and TRP-like proteins appear to couple conformationally with the InsPsR for capacitative Ca*+ entry. The importance of InsPsR signaling in neuronal function has been demonstrated by gene targeting in mice and by studies of T-cell receptor signaling, apoptosis, meiotic maturation, and cytokinesis. Addresses Discs large FKBP FK506-binding protein IICR InsPainduced Ca*+ release inad inactivation no after potential D InsP, inositol 1,4,5trisphosphate InsPsR InsPs receptor opt opisthotonos PCR polymerase chain reaction PDZ PSD-95, Dig. ZO-1 PKC protein kinase C PLC phospholipase C PSD-95 postsynaptic density protein of 95 kDa RyR ryanodine receptor TCR T-cell receptor TRP transient receptor potential TRPL TRP-like zo-1 zona occludens 1 2. Furuichi T, Kohda K, Miyawaki A, Mikoshiba K: Intracellular channels. Curr Opin Neurobiol 1994, 4:294-303. 3. Ross CA, Danoff SK, Schell MJ, Snyder SH: Three additional inositol 1.4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues. Proc Nat/ Acad Sci USA 1992,89:4265-4269. 4. De Smedt H, Missieaen L, Parys JB, Bootman MD, Mertens L, Van Den Bosch L, Casteels R: Determination of relative amounts of inositol trisphosohate receptor mRNA isoforms by ratio polymerese chain reaction. I Biol C/rem 1994, 269:21691-21698. 5. Parys JB, Missiaen L, De Smedt H, Sienaert I, Casteels R: Mechanisms responsible for quantel Cal+ release from inositol triophosphate-sensitive celcium stores. fur J Physioll996, 432:359-367. 6. Nahorski SR, Potter BL: Molecular recognition of inositol polyphosphates by intracellular receptors and metabolic enxymes. fiends Pharmacol Sci 1969, IO:1 39-l 44. Z 8. 9. 10. 11. 12. . . Wilcox RA, Challiss RAJ, Traynor JR, Fauq AH, Ognayanov VI, Korikowski AP, Nahorski SR: Molecular recognition at the myo-inositol 1,4,5+isphosphate receptor. J Biol Chem 1994, 269:26615-26821. O'Rouke F, Feinstein MB: The inositol 1 ,4.5-trisphosphate receptor binding sites of platelet membranes. Biochem J 1990, 267:297-302. Mignery GA, SiJdhof TC: The ligand binding site and transduction mechanism in the inositol 1,4,5+isphosphate receptor. EM60 J 1990, 9:3893-3696. Miyawaki A, Furuichi T, Ryou Y, Yoshikawa S, Nakagawa T, Saitoh T, Mikoshiba K: Structure-function relationships of the mouse inositol 1,4,6-trisphosphate receptor. Proc fiat/ Acad Sci USA 1991, 96:491 l-491 5. Newton CL, Mignery GA, Siidhof TC: Co-expression in vertebrate tissues and cell lines of multiple inositol 1,4,5trisphosphate (InsPs) receptors with distinct affinities for InsPs. J Biol Chem 1994, 26826616-28619. Brillantes A-M, Ondrias K, Scott A, Kobrinsky E, Ondriasova E, Moschella MC, Jayaraman T, Landers M, Ehrfich BE, Marks AR: Stebilization of celcium releese channel (ryenodine receptor) function by FK506-binding protein. Cell 1994, 77:513-523. Timerrnan AP, Wiederrecht G, Marcy A, Fleischer S: Characterization of an exchange reaction between soluble FKBP-12 and the FKBP/ryanodine receptor complex. J Viol Chem 1995, 270:2451-2459. Cameron AM, Steiner JP, Roskarns Al, Ali SM, Ronnett GV, Snyder SH: Calcineurin associated with the inositol 1,4,5trisphosphate receptor-FKBP12 complex modulates Ca*+ flux Cell 1995, 83~463-472.