NIEHS/FDA CLARITY-BPA Research Program Update (original) (raw)

Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

This opinion describes the assessment of the risks to public health associated with bisphenol A (BPA) exposure. Exposure was assessed for various groups of the human population in three different ways: (1) external (by diet, drinking water, inhalation, and dermal contact to cosmetics and thermal paper); (2) internal exposure to total BPA (absorbed dose of BPA, sum of conjugated and unconjugated BPA); and (3) aggregated (from diet, dust, cosmetics and thermal paper), expressed as oral human equivalent dose (HED) referring to unconjugated BPA only. The estimated BPA dietary intake was highest in infants and toddlers (up to 0.875 µg/kg bw per day). Women of childbearing age had dietary exposures comparable to men of the same age (up to 0.388 µg/kg bw per day). The highest aggregated exposure of 1.449 µg/kg bw per day was estimated for adolescents. Biomonitoring data were in line with estimated internal exposure to total BPA from all sources. BPA toxicity was evaluated by a weight of ev...

Author ' s response to reviews Title : A Round Robin Approach to the Analysis of Bisphenol A ( BPA ) in Human

2014

Laura N Vandenberg (lvandenberg@schoolph.umass.edu) Roy R Gerona (roy.gerona@ucsf.edu) Kurunthachalam Kannan (kkannan@wadsworth.org) Julia A Taylor (TaylorJA@missouri.edu) Richard B van Breeman (breemen@uic.edu) Carrie A Dickenson (dickensona@obgyn.ucsf.edu) Chuynyan Liao (cxl12@health.state.ny.us) Yang Yuan (yuanyang0819@gmail.com) Retha R Newbold (newbold1@niehs.nih.gov) Vasantha Padmanabhan (vasantha@med.umich.edu) Frederick S vom Saal (vomsaalf@missouri.edu) Tracey J Woodruff (woodrufft@obgyn.ucsf.edu)