C0078: Relationship Between Extracellular and Intracelular Calcium Mobilization and Platelet Granule Secretion (original) (raw)

Thrombosis Research, 2014

Abstract

ABSTRACT Changes in cytosolic calcium concentration ([Ca2+]c) regulate phosphorylation of importante intracellular signaling players, cytoskeleton reorganization, granule secretion and shape change in platelets among others, being all of them important mechanisms that are required for platelet activation and aggregation. Thrombin (Thr) activates protease activated receptors (PAR1 and PAR4) and promotes platelet stimulation, resulting in the differential release of calcium (Ca2+) located into different intracellular stores, which in turn activate a mechanism of Ca2+ entry from the extracellular medium into the cell, referred as store-operated Ca2+ entry (SOCE). SOCE is considered the main mechanism of Ca2+ entry into platelets and is essential from platelet function. A crucial step during platelet function is the release of physiologic agonists stored inside granules located in the cytosol to the extracellular compartment during activation. Aim. Study the role of Ca2+ mobilization from different intracellular stores or entry from extracellular medium in platelet granule secretion.

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