EPSP Amplification and the Precision of Spike Timing in Hippocampal Neurons (original) (raw)

pathetic ganglion cells (Cassell and McLachlan, 1986) and in granule cells of the olfactory bulb (Schoppa and 25 rue de Dr Roux 75724 Paris Westbrook, 1999). EPSP shaping by postsynaptic conductances is im-France portant in the integration of subthreshold synaptic signals. In pyramidal cells, for instance, EPSP amplification augments the efficacy of dendritic synapses, so com-Summary pensating for an attenuation of distal events (Andreasen and Lambert, 1998). However, signaling at excitatory The temporal precision with which EPSPs initiate acsynapses also comprises a graded dimension of infortion potentials in postsynaptic cells determines how mation coding that lies in the variability in timing of activity spreads in neuronal networks. We found that synaptically induced firing. At some junctions, including small EPSPs evoked from just subthreshold potentials the Calyx of Held synapse (Brew and Forsythe, 1995) initiated firing with short latencies in most CA1 hippoand synapses terminating on other auditory neurons campal inhibitory cells, while action potential timing (Koyano et al., 1996) and on spinal motoneurons (Fetz in pyramidal cells was more variable due to plateau

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