IL-10 production by CD4+ effector T cells: a mechanism for self-regulation (original) (raw)
Regulatory Role of T Cells Producing both Interferonand Interleukin 10 in Persistent Infection
Giorgio Trinchieri
2000
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In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
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The Journal of Immunology
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Requirement for In Vivo Production of IL4, But Not IL10, in the Induction of Proliferative Suppression by Filarial Parasites1
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Experimental Models for the Analysis of IL-10 Function
Alan Sher
2006
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In the Absence of IL-12, CD4+ T Cell Responses to Intracellular Pathogens Fail to Default to a Th2 Pattern and Are Host Protective in an IL-10−/− Setting
Alan Sher
Immunity, 2002
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Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii
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IL-10 Is Critical for Host Resistance and Survival During Gastrointestinal Helminth Infection
Lisa Schopf
The Journal of Immunology, 2002
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Interleukin-10 (IL-10) Counterregulates IL-4-Dependent Effector Mechanisms in Murine Filariasis
Achim Hoerauf
Infection and Immunity, 2004
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Interleukin10 (IL10) in Experimental Visceral Leishmaniasis and IL10 Receptor Blockade as Immunotherapy
Andre Moreira
Infection and Immunity, 2002
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IL-10 is critical for Th2 responses in a murine model of allergic dermatitis
Dhafer Laouini
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IL-10 is not required to prevent immune hyperactivity during memory responses to Toxoplasma gondii
Emma Wilson
Parasite Immunology, 2004
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Altered Immune Responses in Interleukin 10Transgenic Mice
Hilde Cheroutre
Journal of Experimental Medicine, 1997
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Cytokine Production of CD8 + Immune T Cells but Not of CD4 + T Cells from Toxoplasma gondii -Infected Mice Is Polarized to a Type 1 Response Following Stimulation with Tachyzoite-Infected Macrophages
Xiangshu Wen
Journal of Interferon & Cytokine Research, 2006
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Parasitic Infection Cell-Mediated Pathogenicity during Oxide Synthase-Producing Dendritic IL10 Dampens TNF/Inducible Nitric
Alain Beschin
2010
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Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response
Holly Webster
2021
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B-Cell Outgrowth and Ligand-Specific Production of IL-10 Correlate with Th2 Dominance in Certain Parasitic Diseases
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Experimental Parasitology, 1996
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Absence of regulatory IL-10 enhances innate protection against filarial parasites by a neutrophil-independent mechanism
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Conventional T-bet+Foxp3- Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
mark wilson
Journal of Experimental Medicine, 2007
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IL-10 Is Required for Prevention of Necrosis in the Small Intestine and Mortality in Both Genetically Resistant BALB/c and Susceptible C57BL/6 Mice Following Peroral Infection with Toxoplasma gondii
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The Journal of Immunology, 2000
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Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation
Alan Sher
Proceedings of the National Academy of Sciences of the United States of America, 1992
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Interleukin-10 production by effector T cells: Th1 cells show self control
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Hijacking and exploitation of IL-10 by intracellular pathogens
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Trends in Microbiology, 2001
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Expression of Interleukin10 in Intestinal Lymphocytes Detected by an Interleukin10 Reporter Knockin tiger Mouse
Maria Lara
Immunity, 2006
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Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection withToxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control
Matthias Lochner
European Journal of Immunology, 2004
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Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo
Alan Sher
Journal of immunology (Baltimore, Md. : 1950), 1997
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IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease
Alan Sher
The Journal of Immunology, 1998
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IL-10 Dampens TNF/Inducible Nitric Oxide Synthase-Producing Dendritic Cell-Mediated Pathogenicity during Parasitic Infection
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The Journal of Immunology, 2009
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Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite
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Proceedings of the National Academy of Sciences, 2006
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Identification and characterization of IL-10/IFN- -producing effector-like T cells with regulatory function in human blood
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Journal of Experimental Medicine, 2009
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Cytokine Production in Acute versus Chronic Human Schistosomiasis Mansoni: The Cross‐Regulatory Role of Interferon‐γ and Interleukin‐10 in the Responses of Peripheral Blood Mononuclear Cells and Splenocytes to Parasite Antigens
Paulo Miranda
Journal of Infectious Diseases, 1999
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Endogenous IL-10 regulates IFN-gamma and IL-5 cytokine production and the granulomatous response in Schistosomiasis mansoni-infected mice
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Immunology, 1998
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Trypanosoma cruzi:IL-10, TNF, IFN-γ, and IL-12 Regulate Innate and Acquired Immunity to Infection
Ises Abrahamsohn
Experimental Parasitology, 1996
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Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts
Alan Sher
Proceedings of the National Academy of Sciences, 1993
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