Purification and immunoglobulin E-binding properties of peanut allergen Ara h 6: evidence for cross-reactivity with Ara h 2 (original) (raw)

Peanut allergy presents a significant public health challenge due to its increasing prevalence and severe allergic reactions. Recent studies have identified Ara h 6 as a major peanut allergen, exhibiting immunoglobulin E (IgE)-binding properties and evidence of cross-reactivity with Ara h 2. This study focused on purifying Ara h 6 and assessing its allergenic potential through in vitro and in vivo assays, demonstrating that Ara h 6 can elicit strong allergic responses comparable to those of Ara h 2. These findings highlight the importance of Ara h 6 in peanut allergenicity and suggest that it may play a critical role in the diagnosis and management of peanut allergies.