Pseudoallosteric modulation by (+)-MK801 of NMDA (N-methyl-D-aspartate)-coupled phencyclidine binding sites (original) (raw)

Life Sciences, 1990

Abstract

Two high affinity phencyclidine (PCP) binding sites, labeled by (³H)1-(1-(2-thienyl)cyclohexyl)piperidine ((³H)TCP), have been identified in guinea pig brain, with one site coupled to the N-methyl-D-aspartate (NMDA) receptor (site 1) and the other site associated with the dopamine reuptake carrier complex (site 2). In this study, PCP enhanced the dissociation of (³H)TCP from PCP site 1 and site 2, while (+)-MK801

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