VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes (original) (raw)

Vascular endothelial growth factor A (VEGF-A) produced by chronically inflamed tissues plays a crucial role in inducing lymphangiogenesis in draining lymph nodes. The study investigates the mechanisms through which VEGF-A influences lymphatic endothelial cell (LEC) proliferation and lymphangiogenesis during chronic inflammation scenarios, such as in a model of delayed-type hypersensitivity (DTH) in mice. Key findings include a significant increase in the number of LECs and lymphatic structures in lymph nodes draining inflamed tissues. Furthermore, the blockade of VEGF-A significantly inhibited inflammation-induced lymphangiogenesis, indicating its pivotal role in this process.