Caspase-3 Cleaves and Inactivates the Glutamate Transporter EAAT2 (original) (raw)

2006, Journal of Biological Chemistry

4 The abbreviations used are: ALS, amyotrophic lateral sclerosis; EAAT, excitatory amino acid transporter; (Tr)EAAT2, truncated EAAT2 derived from caspase-3 cleavage at the consensus site; CTE, C-terminal domain of EAAT2; SOD1, Cu 2ϩ /Zn 2ϩ -superoxide dismutase; mutSOD1, mutant human SOD1; CHAPS, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid.; DTT, dithiothreitol; Z, benzyloxycarbonyl; fmk, fluoromethyl ketone; PARP, poly(ADP-ribose) polymerase; WT, wild type.

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