Vasoactive mediator release by fetal endothelial cells in intrauterine growth restriction and preeclampsia (original) (raw)

This study investigates the release of vasoactive mediators by fetal endothelial cells in the context of intrauterine growth restriction (IUGR) and preeclampsia. It highlights the impaired conversion of uteroplacental spiral arteries, leading to increased resistance and reduced blood flow, which may trigger compensatory mechanisms involving vasodilators like nitric oxide and prostacyclin. Through the analysis of human umbilical vein endothelial cells, the research compares nitric oxide and prostacyclin synthesis across normal pregnancies, preeclampsia, and fetal growth restriction, revealing significant alterations in these mediators' levels.