Antimicrobial study of the resinous exudates and of diterpenoids and flavonoids isolated from some Chilean Pseudognaphalium (Asteraceae) (original) (raw)
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Journal of Ethnopharmacology, 1998
The antimicrobial properties of the resinous exudate from twigs and leaves of Eupatorium salvia were tested against five Gram-negative and five Gram-positive bacteria. Comparison of the antimicrobial activities of 7-hydroxy-8(17)-labden-15-oic acid (salvic acid) and of its acetate, both compounds isolated from the plant, with that of the crude extract suggested that the latter ester derivative was the major active component
"The antibacterial properties of the resinous exudates from Haplopappus litoralis, H. chrysantemifolius and H. scrobiculatus from Central Chile were assessed against Gram negative and Gram-positive bacteria, and proved active against the latter. The results show that the antibacterial activities of the resinous exudates are independent from the flavonols isolated from each extract that proved to be inactive. The estimated lipophilicity of the flavonols isolated from the Haplopappus resinous exudates were compared with the lipophilicity of known antibacterial flavonols. This analysis showed that lipophilicity is an important variable to predict the antibacterial activity of flavonols."
Antimicrobial and phytochemical analysis of some indigenous plants
World Researchers Associations, 2019
The antimicrobial activity of the extracts of the Calotropis procera, Datura metel, Cuscuta reflexa, Pongamia pinnata and Nerium oleander has been studied against the pathogenic bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aureuginosa, Klebsiella pneumoiniae, Paenibacillus and Bacilus subtilis. Significant antibacterial activity was observed with extract of ethanol, methanol and chloroform. The ethanol extract of D. metel showed maximum antibacterial activity against the all tested bacteria except the P. aureuginosa. Aqueous extract showed no measurable antibacterial activity. Inhibition was seen as concentration dependent phenomenon. Phytochemical screening revealed the presence of alkaloids, flavanoids, glycosides, steroids, tannins, phenol and saponin.
Analysis of Antimicrobial Properties of Some Ethnomedicinal Plants
Journal of Pharmaceutical Research International, 2021
The world is suffering through large number of diseases which are primarily caused by the microbes, though it is bacteria, fungi, viruses or protozoans. The inappropriate, prolonged use of antibiotics and loss of biodiversity and climate change is leading to the invasion of microbes in the human population, because of which every individual on the earth is suffering from diseases caused by microorganisms. In current scenario it is the prerequisite to screen the effective, safe, cheap, and available therapeutics from plants and natural products. Plant parts of sixteen medicinal plant species such as Aegle marmelos, Allium cepa, Allium sativum, Azadirachta indica, Calotropis procera, Cassia fistula, Catharanths roseus, Coriandrum sativum, Curcuma longa, Emblica officinalis, Eucalyptus, Mentha piperita, Nerium oleander, Ocimum sanctum, Withania somnifera and Zingiber officinale with high antimicrobial activity against Gram-positive bacteria Bacillus subtilis, Gram-negative Escherich...
Antibacterial and antifungal activities of crude plant extracts from Colombian biodiversity
Revista de Biología Tropical, 2012
On a global scale, people have used plants to treat diseases and infections, and this has raised interest on the plant biodiversity potencial in the search of antimicrobial principles. In this work, 75 crude n-hexanes, dichloromethane and methanol extracts from the aerial parts of 25 plants belonging to four botanical families (Asteraceae, Euphorbiaceae, Rubiaceae and Solanaceae), collected at the Natural Regional Park Ucumari (Risaralda, Colombia), were evaluated for their antibacterial and antifungal activities by the agar well diffusion method. The antibacterial activities were assayed against two Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis, and three Gram-negative ones named, Klebsiella pneumoniae, Escherichia coli and Pseudomonas aeruginosa. In addition, the same plant extracts were tested against the yeast Candida albicans and the fungi Aspergillus fumigatus and Fusarium solani. Overall, the plant extracts examined displayed better bactericide rather than fungicide activities. In general, the best antibacterial activity was showed by the plant extracts from the Rubiaceae family, followed in order by the extracts from the Euphorbiaceae and Solanaceae ones. It is important to emphasize the great activity displayed by the methanol extract of Alchornea coelophylla (Euphorbiaceae) that inhibited four out of five bacteria tested (B. Subtilis, P. aeruginosa, S. aureus and E. coli). Furthermore, the best Minimal Inhibitory Concentration for the extracts with antifungal activities were displayed by the dichloromethane extracts from Acalypha diversifolia and Euphorbia sp (Euphorbiaceae). The most susceptible fungus evaluated was F. Solani since 60% and 20% of the dichloromethane and methanol extracts evaluated inhibited the growth of this phytopathogenic fungus. The antimicrobial activity of the different plant extracts examined in this work could be related to the secondary metabolites contents and their interaction and susceptibility of pathogenic microorganism evaluated.
Three bacterial isolates were identified from infected potato tubers showing soft and blackleg like symptoms as well as one isolate from infected pear tree showing crown gall symptom. Conventional and molecular identification proved that bacterial isolates belonging to Pectobacterium carotovorum subsp. carotovorum, Pectobacterium atrosepticum, Dickeya solani and Agrobacterium tumefaciens. The above plant bacterial isolates and human pathogenic bacteria Escherichia coli, Sarcina lutea, and Staphylococcus aureus were used for the bioassay. The chloroform leaf extracts from Duranta plumieri variegata, Lantana camara, and Citharexylum spinosum were assayed for their antibacterial activity by measuring the inhibition zones and minimum inhibitory concentrations (MICs). The suggested chemical compositions of extracts were analyzed using GC/MS apparatus. The main compounds in leaf extract of L. camara were 5,8-diethyl-dodecane, pyrimidin-2-one, 4-[N-methylureido]-1-[4-methylaminocarbonyloxymethyl, oleic acid,3-(octadecyloxy)propyl ester; in D. plumieri were 4,7-dimethoxy-2-methylindan-1-one and 5-(hexadecyloxy)-2-pentadecyl-,trans-1,3-dioxane; and in C. spinosum were N-[5-(3-hy-droxy-2-methylpropenyl)-1,3,4,5-tetrahydrobenzo[cd]indol-3-yl]-N-methylacetamide. Promising activity was found against A. tumefaciens, E. coli, P. carotovorum, Sar. lutea, and Staph. aureus with MIC values of 8, 128, 64, 500 and 500 μg/mL, respectively, as L. camara leaf extract was applied. D. plumieri leaf extract showed good activity against D. solani and P. atrosepticum with MIC values of 16 μg/mL and 128 μg/mL, respectively. On the other hand, weak bioactivity was found with leaf extract from C. spinosum. It could be concluded that leaf extracts from D. plumieri and L. camara have a promising antibacterial agents.
CMU Journal of Science, 2021
With growing reports of multidrug-resistant pathogens causing untreatable human infections, the need for new antimicrobial therapies is becoming increasingly important. This study was conducted to investigate the antimicrobial properties of the leaf extracts of Premna odorata Blanco, Petersianthus quadrialatus Merr., Shorea astylosa Foxw., and Tridax procumbens Linn. The medicinal importance of these plants remains understudied despite their abundant distribution and endemism in the Philippines. A disk diffusion assay was utilized to test the antimicrobial properties of T. procumbens leaf extract against Pseudomonas aeruginosa and Staphylococcus aureus. On the one hand, the fungal colony and spore germination assay was used to test P. odorata, P. quadrialatus, and S. astylosa leaf extracts against Aspergillus niger. Different concentrations of leaf extracts were prepared and compared with positive and negative controls. T. procumbens minimally inhibits the growth of P. aeruginosa (10 mm) and S. aureus (10 mm), while S. astylosa leaf extracts revealed the most significant inhibition on colony growth (5.38 mm) and spore germination (15). P. odorata and P. quadrialatus showed the least (28.35 mm; 82.17) and moderate (10.97 mm; 49.5) inhibitory potentials, respectively. The discovery of new antimicrobial compounds from these plant extracts is seen as a potential resolve to the pressing problem of antimicrobial resistance.
Phytochemical Analysis and Antimicrobial Activity of Various Indigenous Plant Species
International Journal for Research in Applied Science & Engineering TechnologyInternational Journal for Research in Applied Science & Engineering Technology, 2021
Plants in the nature constitute various unidentified and excellent properties that can be used for various different purposes including creation of new drugs and therapies. The methanol extract of six medicinal plants i.e., Azadirachta indica (Neem) Calotropis procera (Aakh), Saraca asoca (Ashok), Ocimum tenuiflorum (Tulsi), Asparagus racemosus (Shatavari) and Withania somnifera (Ashwagandha) showed significant antibacterial activity against Escherichia coli, and antifungal activity against Aspergillus niger. Ocimum tenuiflorum(Tulsi) and Asparagus racemosus(Shatavari) leaf extract showed highest antimicrobial activity against E.coli and A.niger. The invitro antimicrobial activity was performed by agar disc diffusion method. The use of plant extracts with known antimicrobial properties, can be of great significance in therapeutic treatments. The study also prove that several plant extracts can be useful in preservation of food articles and constitution of several food preservatives. The presence of phytochemicals is medicinally important for formulation of many therapeutic drugs.