CD8 T Cell Sensory Adaptation Dependent on TCR Avidity for Self-Antigens (original) (raw)

The study examines the role of CD8 T cell sensory adaptation in relation to T cell receptor (TCR) avidity for self-antigens. It discusses how the mature TCR repertoire is shaped by negative selection processes during thymic differentiation, which aim to prevent autoimmunity by ensuring that high avidity TCRs are eliminated. However, the researchers highlight that some self-reactive T cells can escape this deletion and how mechanisms like the tunable activation threshold hypothesis contribute to the maintenance of self-tolerance. Through experimentation involving ZAP-YEEI-expressing T cells, the paper further explores the adaptation mechanisms of T cells in response to self-antigens, revealing key insights into T cell responsiveness and potential implications for autoimmune conditions.