PDC and the protozaon parasite (original) (raw)

This paper reviews the concept of programmed cell death (PCD), with a specific focus on its role in protozoan parasites. It contrasts the historically cautious acceptance of PCD in metazoans, particularly mammals, with the emerging understanding of PCD's potential significance in protozoa. The discussion highlights how similar apoptotic mechanisms may exist across species but emphasizes the evolutionary distance that suggests diverging molecular pathways. The influence of PCD on the biology of both the host and the parasites offers insights into disease processes, particularly in the context of infections like leishmaniasis.