Developmental fate of hematopoietic stem cells: The study of individual hematopoietic clones at the level of antigen-responsive B lymphocytes (original) (raw)

The study investigates the developmental fate of hematopoietic stem cells (HSCs) by tracking individual hematopoietic clones at the level of antigen-responsive B lymphocytes. It highlights the dynamics of hematopoiesis, revealing that while most clones exhibit short lifespans, a small fraction contributes to long-term cell maintenance in mice. Implementing a novel technique for clonal tracking using splenic B cells, the research underscores its potential for further examining hematopoietic cell lineages, particularly in the context of gene therapy and other applications.