< i> In vitro antileishmanial and antitrypanosomal activities of flavanones from< i> Baccharis retusa DC.(Asteraceae) (original) (raw)

Experimental parasitology, 2011

Abstract

Leishmaniasis and Chagas' are parasitic protozoan diseases that affect the poorest population in the world, causing a high mortality and morbidity. As a result of highly toxic and long-term treatments, novel, safe and more efficacious drugs are essential. In this work, the CH2Cl2 phase from MeOH extract from the leaves of Baccharis retusa DC.(Asteraceae) was fractioned to afford two flavonoids: naringenin (1) and sakuranetin (2). These compounds were in vitro tested against Leishmania spp. promastigotes and amastigotes and ...

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