Concentration- and time-dependent effects of γ-linolenic acid supplementation to tumor cells in culture (original) (raw)

Abstract

Gamma-linolenic acid (GLA) supplemented to neuroblastoma SK-N-BE, tubal carcinoma TG and colon carcinorna SW-620 cells was incorporated into phospholipids in all the cell lines (although to different extents), in a concentration-and time-dependent manner. All the cell lines were able to metabolize GLA to arachidonic acid, SK-N-BE being the most active. Supplementation with low GLA concentrations for short periods was not sufficient to impair cell proliferation; only higher amounts of GLA had an anti-proliferative effect also in short times. In these conditions, the antiproliferative effect of GLA is probably due to cellular dysfunction caused by fatty acid modifications.

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