Antidiabetic and antihyperlipidaemic potential of< i> Amaranthus viridis(L.) Merr. in streptozotocin induced diabetic rats (original) (raw)
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Phytochemical and Pharmacological potential of Amaranthus viridis L.– A Review
Medicinal plants are important in the traditional medicine and as well as modern pharmaceutical drugs. In traditional system of medicine various plant parts like leaves, flowers, stems, fruits, seeds, barks and even whole plants are used for the treatment. Traditionally the leaves, seeds, roots and entire plant of Amaranthus viridis Linn is used in the treatment of many diseases. Its uses include diuretic, analgesic, antipyretic, vermifuge, antiulcer antidiabetic, anti-cholesterolemic, laxative, asthma and veneral diseases. This review encompasses the available literature on Amaranthus viridis with respect to its pharmacognostic characters, physicochemical parameters, synopsis of pharmacological activities and traditional uses. This attempt provides a direction towards further research.
Bioeduscience, 2023
Background: Amaranthus viridis L. an herbal plant belonging to the family Amaranthaceae, has gained significant attention in the field of traditional medicine due to its rich chemical composition. This plant is known to contain various bioactive components that contribute to its pharmaceutical value. With its extensive range of chemical compounds, Amaranthus viridis L. has found applications in the therapeutic, pharmaceutics, and cosmetic industries. In this study, we aim to explore the medicinal potential of Amaranthus viridis and investigate its various pharmaceutical activities. Methods: The process of writing this review involved conducting comprehensive electronic research using reputable sources, including international and national article databases, along with books accessed through platforms like Google Scholar, PubMed, IEEE Xplore, ScienceDirect, and others. The gathered data is subsequently analyzed, followed by employing synthetic approaches with narrative methods to derive meaningful conclusions and interpretations. Results: Amaranthus viridis L. displays potent antioxidant and anti-inflammatory properties, attributed to its rich composition of flavonoids, cardiac glycosides, and zinc. Its diverse pharmaceutical activities make it a promising contender for medicinal use, addressing labor pain, skin conditions like eczema and psoriasis, and respiratory issues, while also exhibiting antimicrobial effects against bacteria, fungi, and parasites. It can be accomplished by Extraction with solvent, Phytochemical screening, and Isolation and purification. Conclusion: Amaranthus viridis L. an herbal plant, shows significant potential in the therapeutic, pharmaceutics, and makeup industries. Its bioactive compounds, including flavonoids, cardiac glycosides, and zinc, contribute to its diverse pharmaceutical activities, such as antioxidant, anti-inflammatory, antibacterial, antifungal, antidiabetic, and antihelmintic properties.
International Journal of Pharmaceutical Archive, 2012
Hypoglycaemic activity and Hypolipidaemic potential of aerial parts of Amaranthus viridis (L.) Merr.in streptozotocin induced diabetic rats. Objective: The present study is planned to investigate the Hypoglycaemic activity and hypolipidaemic potential of aerial parts of Amaranthus viridis aqueous extract (AVAE) in Stz-induced diabetic rats. Methods: Diabetes was induced in rats by single intraperitoneal injection of STZ (55mg/kg b.wt.). After 72 h rats with marked hyperglycaemia (fasting blood glucose ≥250 mg/dl) were selected and used for the study. Antidiabetic activity was evaluated by administration of AVAE orally at the doses of 100,200 and 400 mg/kg body weight for 30 days. Glibenclamide (500 ug/kg) was used as the reference drug. Fasting blood glucose and lipid parameters, viz. triglycerides, total cholesterol, high density lipoprotein and low density lipoprotein levels were measured. Results: In STZ-induced diabetic rats, repeated administration of AVAE significantly (P < 0.05) decreased the blood glucose level in a dose-dependent manner during the 30 days of treatment period. AVAE modulated lipid profile changes in STZ-diabetic rats in a dose-dependent manner. Conclusions: The significant control of serum lipids levels in the AVAE treated diabetic rats may be directly attributed to improvement in glycemic control upon AVAE therapy. Hence, these findings demonstrate that the aqueous extract of aerial parts of Amaranthus viridis has the potential to treat diabetes mellitus and complications owing to its hypoglycaemic activity and hypolipidaemic effect.