Validation of Trypanosoma brucei trypanothione synthetase as drug target (original) (raw)

Valdiation of Trypanosoma brucei trypanothione synthetase as drug target

Free Radical Biology and Medicine, 2004

Gene Knockdown of -Glutamylcysteine Synthetase by RNAi in the Parasitic Protozoa Trypanosoma brucei Demonstrates That It Is an Essential Enzyme

Trang Vo Huynh

Journal of Biological Chemistry, 2003

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Gene Knockdown of γ-Glutamylcysteine Synthetase by RNAi in the Parasitic Protozoa Trypanosoma brucei Demonstrates That It Is an Essential Enzyme

Margaret Harmon

Journal of Biological Chemistry, 2003

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Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei

Stuart McElroy

ChemMedChem, 2009

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Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis

Preeti Kapoor

Journal of Experimental Medicine, 1981

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Targeting the nucleotide metabolism of Trypanosoma brucei and other trypanosomatids

Anders Hofer

FEMS Microbiology Reviews

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Allosteric Regulation of Trypanosoma bruceiRibonucleotide Reductase Studied in Vitro and in Vivo

Anders Hofer

Journal of Biological Chemistry, 1998

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Trypanosoma brucei γ-Glutamylcysteine Synthetase

margaret phillips

Journal of Biological Chemistry, 1998

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Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi

CITLALI SHEREZADA GONZALEZ VAZQUEZ

FEBS letters, 2017

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Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Joseph Luft

Molecular Microbiology, 2008

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Metabolic control analysis of the Trypanosoma cruzi peroxide detoxification pathway identifies tryparedoxin as a suitable drug target

Rafael Moreno-Sánchez

Biochimica et Biophysica Acta (BBA) - General Subjects, 2015

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Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

Antonio Ariza

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Dissecting the Catalytic Mechanism of Trypanosoma brucei Trypanothione Synthetase by Kinetic Analysis and Computational Modeling

Alejandro Leroux

Journal of Biological Chemistry, 2013

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Catalytic mechanism of the glutathione peroxidase-type tryparedoxin peroxidase of Trypanosoma brucei

Thomas Ruppert

Biochemical Journal, 2007

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Ebsulfur Is a Benzisothiazolone Cytocidal Inhibitor Targeting the Trypanothione Reductase of Trypanosoma brucei

Anna-lena Gustavsson

Journal of Biological Chemistry, 2013

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Diverse Effects on Mitochondrial and Nuclear Functions Elicited by Drugs and Genetic Knockdowns in Bloodstream Stage Trypanosoma brucei

Marilyn Parsons

PLoS Neglected Tropical Diseases, 2010

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Discovery of Trypanocidal Compounds by Whole Cell HTS of Trypanosoma brucei

Peter Chiang

Chemical Biology <html_ent glyph="@amp;" ascii="&"/> Drug Design, 2006

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Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

francesca moraca

Molecules, 2021

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Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

Marcelo Comini

Biochimica et Biophysica Acta (BBA) - General Subjects, 2008

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Gamma-glutamylcysteine synthetase and tryparedoxin 1 exert high control on the antioxidant system in Trypanosoma cruzi contributing to drug resistance and infectivity

Citlali Vazquez

Redox Biology, 2019

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Genetic and Chemical Evaluation of Trypanosoma brucei Oleate Desaturase as a Candidate Drug Target

Silvia Altabe, Andrés Alloatti

PLoS ONE, 2010

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Trypanosoma brucei: an evaluation of salicylhydroxamic acid as a trypanocidal drug

Fred Opperdoes, Piet Borst

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The Dithiol Glutaredoxins of African Trypanosomes Have Distinct Roles and Are Closely Linked to the Unique Trypanothione Metabolism

Carsten Berndt

Journal of Biological Chemistry, 2010

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Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification

Leopold A N Flohe

Free Radical Biology and Medicine, 2008

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Molecular characterisation of mitochondrial and cytosolic trypanothione-dependent tryparedoxin peroxidases in Trypanosoma brucei

Alan Prescott

Molecular and Biochemical Parasitology, 2001

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Lipoamide dehydrogenase is essential for both bloodstream and procyclic Trypanosoma brucei

Marcelo Comini

Molecular Microbiology, 2011

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Glutathione and trypanothione in several strains of Trypanosoma cruzi: Effect of drugs

Eduardo Opazo

Comparative Biochemistry and Physiology B-biochemistry & Molecular Biology, 1996

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Solanesyl Diphosphate Synthase, an Enzyme of the Ubiquinone Synthetic Pathway, Is Required throughout the Life Cycle of Trypanosoma brucei

Marta Dubin

Eukaryotic Cell, 2013

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Thiol Metabolism of the Trypanosomatids as Potential Drug Targets

Daniel Jacobus J Steenkamp

International Union of Biochemistry and Molecular Biology Life, 2002

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In Vitro and In Vivo Activity of Multi-Target Inhibitors Against Trypanosoma brucei

Roberto Docampo

ACS Infectious Diseases, 2015

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Validation of Trypanosoma brucei trypanothione synthetase as drug target (original) (raw)

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