O-GlcNAcylation, contractile protein modifications and calcium affinity in skeletal muscle (original) (raw)

O-GlcNAcylation is an atypical glycosylation process that modulates numerous cellular functions by adding N-acetyl-glucosamine to protein serine and threonine residues. This review explores the dynamic interplay between O-GlcNAcylation, contractile protein modifications, and calcium affinity in skeletal muscle, emphasizing its critical role in cellular processes, stress responses, and implications in various diseases. Recent advancements in methodologies for analyzing O-GlcNAc patterns highlight its importance in understanding muscle physiology and pathology.