Reply to: "Sorafenib or 90Y loaded resin microsphere radioembolization for locally-advanced hepatocellular carcinoma, what should we trust? (original) (raw)

Liver international : official journal of the International Association for the Study of the Liver, 2015

Abstract

There is no doubt that resin and glass (90) Y-loaded microspheres have different specific activities (Bq per sphere) and, hence, the total amount of spheres needed to ensure an adequate radiobiological effect is different. Therefore, we may agree to the semantic issue put forward by Dr. Garin et al. However, we disagree with the argument that the use of the term radioembolization would generate a misinterpretation of the substantial (clinical) message we provided by comparing selective internal radiation therapy (SIRT) with systemic therapy based on sorafenib administration. Indeed, to the best of our knowledge, there is no evidence that one type of microspheres (glass or resin) is superior to the other one for the outcomes we considered, i.e. tumor response, toxicity and patient survival. This article is protected by copyright. All rights reserved.

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