GOLDSMITHS Research Online (original) (raw)

Abstract

Objective: Although early-onset conduct problems predict both psychiatric and health problems in adult life, little research has been done to index neural correlates of conduct problems. Emerging research suggests that a subgroup of children with conduct problems and elevated levels of callous-unemotional traits may be genetically vulnerable to manifesting disturbances in neural reactivity to emotional stimuli indexing distress.

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References (39)

  1. Kim-Cohen J, Caspi A, Taylor A, Williams B, Newcombe R, Craig IW, Moffitt TE: MAOA, maltreatment, and gene-environment in- teraction predicting children's mental health: new evidence and a meta-analysis. Mol Psychiatry 2006; 11:903-913
  2. Odgers CL, Caspi A, Broadbent JM, Dickson N, Hancox RJ, Har- rington H, Poulton R, Sears MR, Thomson WM, Moffitt TE: Pre- diction of differential adult health burden by conduct problem subtypes in males. Arch Gen Psychiatry 2007; 64:476-484
  3. Moffitt TE: Life-course-persistent and adolesence-limited anti- social behavior, in Causes of Conduct Disorder and Juvenile De- linquency. Edited by Lahey BB, Moffitt TE, Caspi A. New York, Guilford, 2003
  4. Frick PJ, Marsee MA: Psychopathy and developmental path- ways to antisocial behavior in youth, in Handbook of Psycho- pathy. Edited by Patrick CJ. New York, Guilford, 2006
  5. Viding E, Jones AP, Frick P, Moffitt TE, Plomin R: Heritability of antisocial behaviour at 9: do callous-unemotional traits mat- ter? Dev Sci 2008; 11:17-22
  6. Viding E, Blair RJR, Moffitt TE, Plomin R: Evidence for substan- tial genetic risk for psychopathy in 7-year-olds. J Child Psychol Psychiatry 2005; 46:592-597
  7. Blair RJ, Colledge E, Murray L, Mitchell DG: A selective impair- ment in the processing of sad and fearful expressions in chil- dren with psychopathic tendencies. J Abnorm Child Psychol 2001; 29:491-498
  8. Blair RJR, Peschardt KS, Budhani S, Mitchell DGV, Pine DS: The development of psychopathy. J Child Psychol Psychiatry 2006; 47:262-275
  9. Blair R, Mitchell DG, Richell RA, Kelly S, Leonard A, Newman C, Scott SK: Turning a deaf ear to fear: impaired recognition of vo- cal affect in psychopathic individuals. J Abnorm Psychol 2002; 111:682-686
  10. Adolphs R: Is the human amygdala specialized for processing social information? Ann NY Acad Sci 2003; 985:326-340
  11. Herba C, Phillips ML: Annotation: development of facial ex- pression recognition from childhood to adolescence: behav- ioural and neurological perspectives. J Child Psychol Psychiatry 2004; 45:1-14
  12. Hariri A, Tessitore A, Mattay V, Fera F, Weinberger D: The amygdala response to emotional stimuli: a comparison of faces and scenes. Neuroimage 2002; 17:317-323
  13. Lobaugh N, Gibson E, Taylor M: Children recruit distinct neural systems for implicit emotional face processing. Neuroreport 2006; 17:215-219
  14. Kiehl KA, Smith AM, Hare RD, Mendrek A, Forster BB, Brink J, Liddle PF: Limbic abnormalities in affective processing by crim- inal psychopaths as revealed by functional magnetic reso- nance imaging. Biol Psychiatry 2001; 50:677-684
  15. Birbaumer N, Veit R, Lotze M, Erb M, Hermann C, Grodd W, Flor H: Deficient fear conditioning in psychopathy: a functional magnetic resonance imaging study. Arch Gen Psychiatry 2005; 62:799-805
  16. Gordon HL, Baird AA, End A: Functional differences among those high and low on a trait measure of psychopathy. Biol Psychiatry 2004; 56:516-521
  17. Veit R, Flor H, Erb M, Hermann C, Lotze M, Grodd W, Birbaumer N: Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans. Neurosci Lett 2002; 328:233-236
  18. Marsh AA, Finger EC, Mitchell DG, Reid ME, Sims C, Kosson DS, Towbin KE, Leibenluft E, Pine DS, Blair RJ: Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disor- ders. Am J Psychiatry 2008; 165:712-720
  19. Paus T: Primate anterior cingulate cortex: where motor con- trol, drive, and cognition interface. Nat Rev Neurosci 2001; 2: 417-424
  20. Meyer-Lindenberg A, Buckholtz JW, Kolachana B, Hariri AR, Pezawas L, Blasi G, Wabnitz A, Honea R, Verchinski B, Callicott JH, Egan M, Mattay V, Weinberger D: Neural mechanisms of ge- netic risk for impulsivity and violence in humans. Proc Natl Acad Sci USA 2006; 103:6269-6274
  21. Sterzer P, Stadler C, Krebs A, Kleinschmidt A, Poutska F: Abnor- mal neural responses to emotional visual stimuli in adoles- cents with conduct disorder. Biol Psychiatry 2005; 57:7-15
  22. Sterzer P, Stadler C, Poustka F, Kleinschmidt A: A structural neu- ral deficit in adolescents with conduct disorder and its associa- tion with lack of empathy. Neuroimage 2007; 37:335-342
  23. Cleckley H: The Mask of Sanity, 5th ed. St Louis, Mosby, 1976
  24. Trouton A, Spinath FM, Plomin R: Twins Early Development Study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition, and behavior problems in childhood. Twin Res 2002; 5:444-448
  25. Piacentini J, Cohen P, Cohen C: Combining discrepant diagnos- tic information from multiple sources: are complex algorithms Am J Psychiatry 166:1, January 2009
  26. AMYGDALA HYPOACTIVITY AND CALLOUS-UNEMOTIONAL TRAITS ajp.psychiatryonline.org better than simple ones? J Abnorm Child Psychol 1992; 20:51- 63
  27. Goodman R: The Strengths and Difficulties Questionnaire: a re- search note. J Child Psychol Psychiatry 1997; 38:581-586
  28. Frick PJ, Hare RD: Antisocial Process Screening Device. Toronto, Multi Health Systems, 2001
  29. Ekman P, Freisen W: Pictures of Facial Affect. Palo Alto, Calif, Consulting Psychologist Press, Inc, 1976
  30. Phillips ML, Young AW, Scott SK, Calder AJ, Andrew C, Giampi- etro V, Williams SC, Bullmore ET, Brammer M, Gray JA: Neural responses to facial and vocal expressions of fear and disgust. Proc Biol Sci 1998; 265:1809-1817
  31. Wechsler D: Wechsler Abbreviated Scales of Intelligence. San Antonio, Tex, Psychological Corporation, 1999
  32. Burgund ED, Kang HC, Kelly JE, Buckner RL, Snyder AZ, Pe- tersen SE, Schlaggar BL: The feasibility of a common stereotac- tic space for children and adults in fMRI studies of develop- ment. Neuroimage 2002; 17:184-200
  33. Kang HC, Burgund ED, Lugar HM, Petersen SE, Schlaggar BL: Comparison of functional activation foci in children and adults using a common stereotactic space. Neuroimage 2002; 19:16- 28
  34. Viding E, Jones AP: Cognition to genes via the brain in the study of conduct disorder. Q J Exp Psychol (Colchester) 2008; 61:171- 181
  35. Eisenberger NI, Way BM, Taylor SE, Welch WT, Lieberman MD: Understanding genetic risk for aggression: clues from the brain's response to social exclusion. Biol Psychiatry 2007; 35: 1601-1612
  36. Buckholtz J, Callicott J, Kolachana B, Hariri A, Goldberg T, Gen- derson M, Egan M, Mattay V, Weinberger D, Meyer-Lindenberg A: Genetic variation in MAOA modulates ventromedial prefron- tal circuitry mediating individual differences in human person- ality. Mol Psychiatry 2008; 13:313-324
  37. Adolphs R, Gosselin F, Buchanan TW, Tranel D, Schyns P, Da- masio AR: A mechanism for impaired fear recognition after amygdala damage. Nature 2005; 433:68-72
  38. van Reekum CM, Johnstone T, Urry HL, Thurow ME, Schaefer HS, Alexander AL, Davidson RJ: Gaze fixations predict brain ac- tivation during the voluntary regulation of picture-induced negative affect. Neuroimage 2007; 36:1041-1055
  39. Dadds MR, Perry Y, Hawes DJ, Merz S, Riddell AC, Haines DJ, So- lak E, Abeygunawardane AI: Attention to the eyes and fear-rec- ognition deficits in child psychopathy. Br J Psychiatry 2006; 189:280-281