Thermodynamic Investigation of Interaction Between the Tilorone and DNA (original) (raw)
2006, Nippon Kagakkai Koen …
AI-generated Abstract
This research investigates the interaction between Tilorone, a small molecule with potential therapeutic applications, and deoxyribonucleic acid (DNA). It provides a comprehensive evaluation of how Tilorone binds to DNA through various non-covalent interactions such as electrostatic attractions and intercalative binding, with a detailed temperature and pH-dependent analysis of binding constants. The findings have significant implications for the development of effective anticancer drugs targeting DNA, highlighting the importance of studying small molecule-DNA interactions.
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