Connexin 37 Limits Thrombus Propensity by Downregulating Platelet Reactivity (original) (raw)

Connexin 37 (Cx37), an isoform expressed in endothelial cells and platelets, plays a critical role in downregulating platelet reactivity, thus limiting thrombus propensity. This study demonstrates that gap junctional intercellular communication (GJIC) between aggregating platelets decreases their tendency to form clots by propagating antiaggregating signals. Furthermore, individuals with the Cx37-1019C allele exhibited a heightened platelet response compared to those with the Cx37-1019T allele, indicating a genetic influence on platelet behavior and potential implications for thrombotic diseases.