Development of a Practical Synthesis of an Aminoindanol-Derived M1 Agonist † (original) (raw)

Development of a Practical Synthesis of an Aminoindanol-Derived M1 Agonist †

Organic Process Research & Development, 2009

Abstract

An efficient and scalable synthesis of the clinical candidate 1 is described. The first-generation synthesis built the enantioenriched nitro-aminoindanol core from 6-nitroindanone using a five-step literature route. The second-generation route used a safe aromatic nitration ...

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