IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production
Christine Falk
Biochemical Pharmacology, 2010
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New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway
Paul Changelian
Current Opinion in Rheumatology, 2005
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STAT3 regulates NF- B recruitment to the IL-12p40 promoter in dendritic cells
Frank Hoentjen
Blood, 2005
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STAT3 regulates NF-kappaB recruitment to the IL-12p40 promoter in dendritic cells
Frank Hoentjen
Blood, 2005
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Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses
Thomas Decker
Frontiers in immunology, 2017
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Prevention of CD40-Triggered Dendritic Cell Maturation and Induction of T-Cell Hyporeactivity by Targeting of Janus Kinase 3
Marcus Saemann
American Journal of Transplantation, 2003
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Specific Jak3 Downregulation in Lymphocytes Impairs γc Cytokine Signal Transduction and Alleviates Antigen-driven Inflammation In Vivo
Jose Perales
Molecular Therapy — Nucleic Acids, 2012
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Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor β-chain
John O'Shea
Cytokine, 1995
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The Role of JAK-3 in Regulating TLR-Mediated Inflammatory Cytokine Production in Innate Immune Cells
Huizhi Wang
The Journal of Immunology, 2013
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JAK-STAT Signaling: From Interferons to Cytokines
David Levy
Journal of Biological Chemistry, 2007
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Mechanistic Insights into Impaired Dendritic Cell Function by Rapamycin: Inhibition of Jak2/Stat4 Signaling Pathway
Clark Bonham
The Journal of Immunology, 2004
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Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK–STAT
章 大野
Proceedings of the National Academy of Sciences, 2005
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Jak-STAT pathway is involved in the induction ofTNF-β gene during stimulation by IL-2
J. Theze
European Journal of Immunology, 1998
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Defective JAK-STAT Pathway Signaling Contributes to Autoimmune Diseases
Charles Malemud
Current Pharmacology Reports, 2018
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Differential Regulation of the Janus Kinase-STAT Pathway and Biologic Function of IL-13 in Primary Human NK and T Cells: A Comparative Study with IL-4
Chengrong Yu
The Journal of Immunology, 1998
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ALL-associated JAK1 mutants activate the JAK/STAT pathway via IL-9Rα homodimers
E. Flex
2009
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Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
Jak Been
Cell, 1996
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The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
farhad seif
Cell communication and signaling : CCS, 2017
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Dominant Negative Stat3 Mutant Inhibits Interleukin-6-induced Jak-STAT Signal Transduction
Allard Kaptein
Journal of Biological Chemistry, 1996
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An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT
Masahiko Hibi
Oncogene, 1997
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Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway
C. Malemud
Pharmaceuticals, 2010
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JAK/STAT Signal Transduction: Promising Attractive Targets for Immune, Inflammatory and Hematopoietic Diseases
sami shaikh
Current Drug Targets, 2018
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The inhibition of JNK and p38 MAPKs downregulates IL-10 and differentially affects c-Jun gene expression in human monocytes
Lyuba Miteva
Immunopharmacology and Immunotoxicology, 2009
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Sensitization of IFN-γ Jak-STAT signaling during macrophage activation
James Woods
Nature Immunology, 2002
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Role of JAK3 in CD40-Mediated Signaling
Georges Khalil
1998
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JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy
Roshitha Shaji
Postgraduate Medicine, 2020
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The regulation of JAKs in cytokine signaling and its breakdown in disease
Juuli Raivola
Cytokine, 2018
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Ex vivo effect of JAK inhibition on JAK-STAT1 pathway hyperactivation in patients with dominant negative STAT3 mutations
Pilar Blanco Lobo
2022
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Suppression of Pro-Inflammatory Cytokines via Targeting of STAT-Responsive Genes
Charles Malemud
Drug Discovery, 2013
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Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation
Stephanie Brandlein
International Immunology, 1999
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“Suppressor of Cytokine Signalling” Molecules in Infection and Inflammation
Martin Rottenberg
Inflammation, Chronic Diseases and Cancer - Cell and Molecular Biology, Immunology and Clinical Bases, 2012
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Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection
Paul Changelian
Journal of Medicinal Chemistry, 2010
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Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis
Dimitra Beroukas
Annals of the Rheumatic Diseases, 2006
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Pathogenic and Therapeutic Relevance of JAK/STAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent
Antonis Fanouriakis
Cells
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Biological and clinical significance of the JAK-STAT pathway; lessons from knockout mice
Peter Igaz
Inflammation Research, 2001
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