Less extensive surgery compared to extensive surgery: survival seems similar in young women with adult ovarian granulosa cell tumor (original) (raw)
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Clinicomorphological Study Of Ovarian Lesions
Journal of Chitwan Medical College, 2014
This prospective study was conducted at College of Medical Sciences-Teaching Hospital (CMS-TH) during December 2008 to May 2010. One hundred and fifty cases were analyzed. Age of the patients, parity, presenting symptoms, types of surgery, clinical diagnosis and complications were retrieved from case sheets. Surface epithelial tumors were more frequently observed above 30 years of age, (62.07%) cases. During 1st to 3rd decades of life, 62.8% germ cell tumors were seen; and sex cord tumors were seen in age group 41-60 years only. For all age groups, benign tumors were common than malignant tumors. There were 10.7% unmarried patients, 5.33% nulliparous, 35.55% of parity 1 to 2; 4% pregnant and 20 % postmenopausal women. There were 86.67% cases neoplastic, and 13.33% non-neoplastic ovarian lesions; 93.85% benign, 5.38% malignant and 0.77% borderline tumors. Surface epithelial tumors were the most common tumors (53.84%) followed by germ cell tumors (43.85%), constituted 46.7% and 38% among all ovarian lesions. The commonest benign tumors were serous cystadenomas and mature cystic teratomas, constituted 40% cases each. Dysgerminoma was the common malignant neoplasm (2.31%), all were seen in adolescents. Most of the other malignant neoplasms were observed above 40 years of age. Seventy percent (70%) of non-neoplastic lesions were hemorrhagic corpus luteum cysts. The commonest presenting symptom was pain in the lower abdomen (82%) followed by abdominal mass/ or distension (48.7%). Constitutional symptoms were observed in malignant cases only. Grossly, majority of the ovarian lesions were of size ranging 5 to 15 cm; and 89.93% cystic lesions. There were 48.7% lesions in the right ovary and 45.3% in the left ovary; 6% bilateral ovarian lesions, all of which were observed in benign and non-neoplastic lesions. The common complication observed was torsion (6.7%) followed by rupture of the cysts (6%).
Analysis of distribution and patterns of ovarian lesions at a tertiary care hospital
Annals of Pathology and Laboratory Medicine, 2018
Background: Ovarian lesions manifest in a wide spectrum of clinical, morphological and histological features. The aim of this study was to analyze the distribution and patterns of these lesions at a tertiary care hospital. Methods: Retreivement and collection of the data was done along with demographic data including age, sex, Ultrasonography/Computed Tomography findings. The diagnosis was confirmed by histopathological examination. Correlation of histopathological patterns was done with age, bilaterality, type, size & morphology of the lesion. Results: Follicular cyst was the commonest non-neoplastic lesion of the ovary. Surface epithelial tumor was the commonest tumor according to the histogenesis followed by germ cell tumor. Among the malignant surface epithelial tumors, commonest type was serous cystadenocarcinoma followed by endometroid carcinoma. Serous cyst adenoma was the commonest tumor in benign category. In germ cell tumors category, benign mature teratomas constituted highest numbers (15 cases). Six cases of sex cord stromal tumor and 2 cases of metastatic tumors were also detected in the study. Conclusions: It is concluded from this study that benign ovarian tumors were more common than malignant ones across all age groups. Though a majority of the tumors were benign, more numbers of malignant tumours were observed in our study as compared to those by other authors, which is an alarming finding. As most of the malignant ovarian tumors present late, development of methods for early diagnosis & regular screening is a pressing need today.
Histopathological Study of Spectrum of Ovarian Lesions
IOSR Journals , 2019
Introduction: Ovarian neoplasms are herterogenous and manifest with wide spectrum of clinical, morphological and histological features. The complex nature, unpredictable behavior, prognosis and controversial management makes ovarian lesions fall in the line of interest. Objectives: This study was undertaken to analyse and characterize the ovarian lesions based on the histopathological features and to find out the frequency of benign and malignant neoplasms studied. Materials and methods: This is a retrospective-prospective study of ovarian lesions conducted at a tertiary care centre, over a period of four and half years. Results: Out of 96cases studied, majority were benign tumors, followed by malignant and borderline ovarian lesions. Most common age group of presentation was 41-50 years. Surface epithelial tumors outnumbered among the ovarian lesions and serous cystadenoma was the most predominant lesion. Conclusion: The ovary is a frequent site for primary and metastatic tumors. The prognosis and varying therapeutic strategies of ovarian tumors necessitate an accurate pathological evaluation. Although newer techniques like IHC and molecular analysis make diagnosis easier and precise, histopathological evaluation still remains gold standard.
2021
Background: Ovarian cancer is the most frequent cause of death from gynaecological cancers and the fourth most frequent cause of death from cancer in women in Europe, United States and India. The present study was conducted to assess distribution of neoplastic and nonneoplastic ovarian lesions. Materials & Methods: 74 patients age ranged 1848 years was recorded. The histological characterization of ovarian tumour was done according to the International Classification of Diseases, (WHO Classification, 1995). Results: Age ranged 1828 years had 24, 28-38 years had 40 and 38-48 years had 10. Common nonneoplastic lesions were simple serous cyst in 13, luteal cyst in 20, salpingooophoritis in 3, hemorrhagic cyst in 8 and endometriosis in 6 patients. Common neoplastic lesions were germ cell tumor seen in 12, epithelial tumors in 6, sex cord stromal tumour in 4 and metastatic tumors in 2 patients. The difference was significant (P< 0.05). Conclusion: Most common nonneoplastic lesions was...
Histopathological spectrum of ovarian tumours-A two year retrospective study
IP Innovative Publication Pvt. Ltd., 2017
Introduction: Almost 80% of the ovarian neoplasms are benign and it is also a common site for primary malignancy, although metastasis to ovaries can also occur. Benign ovarian neoplasms are common in 20-45 years age group. Nulliparity, family history of cancer and genetic mutations are some of the risk factors associated with the development of ovarian neoplasms. Sex cord stromal tumours(SCST) are almost always unilateral while metastatic tumours tend to be bilateral. Most of the benign surface epithelial tumours are cystic while solid tumours with papillary projections seen on gross examination make a diagnosis of malignancy likely. However, microscopic features exhibited by these tumours help in making an accurate diagnosis. Objective: The present two year retrospective study was carried out in the histopathology department of our diagnostic centre from January 2015 to December 2016 to analyse the frequency and histopathological spectrum of ovarian tumours in our setting. Materials and Method: This was a two year retrospective study carried out between January 2015 to December 2016.A total of 146 cases of ovarian specimens were received in formalin in the histopatholgy department .The gross findings were noted and the sections were subjected to paraffin embedding and Hand E staining using standard protocols. The tumours were classified as surface epithelial tumours(SET), sex cord stromal tumours (SST) and germ cell tumours(GCT). The data so obtained was analysed for frequency of these tumours in different age groups. Results: Of the 119 ovarian tumors, 109(91.5%) were benign and 10(8.5%) were malignant. Surface epithelial tumors were most common i.e., 83/ 119(69.7%) followed by germ cell tumors which were 29 out of 119(24.4%), while sex cord stromal tumour were 7 / 119(5.4%). Out of all ovarian neoplasms, serous surface epithelial tumors were the most commonly occurring tumour followed by mature cystic teratomas. Conclusion: Benign ovarian tumours are far more common than their malignant counterparts with surface epithelial tumours being the commonest followed by germ cell tumours, majority presenting in 31-40 years age group. A proper histological diagnosis provides help to the gynaecologist in initiating proper and timely treatment.
Histopathological Study of Spectrum of Ovarian Tumors -A 2 Years Study in a Tertiary Care Institute
IOSR Journals , 2019
Introduction:Ovarian tumours are heterogeneous neoplasms with varied clinical, morphological and histological features. Ovarian tumours account for 3% of cancers in females and is the 5th most common form of cancer related death in females.Epithelial tumors comprise about 60% of all ovarian neoplasms and more than 90% of malignant tumors. Tumors derived from the sex cords or ovarian mesenchyme constitute 5% to 12% of all ovarian neoplasms.Ovarian tumors are often difficult to detect until they are advanced in stage or size, as symptoms are vague and insidious and there is no definite screening programme for early detection. Aims & Objectives:To study the incidence, age distribution and diverse histomorphological spectrum of ovarian tumours. Materials & Methods:This Prospective study of 2 years duration comprised of 116 ovarian neoplasms diagnosed in the department of pathology, in a tertiary care institute. After obtaining clinical data from the records and gross examination, tissue samples from representative area were fixed in formalin, routinely processed, embedded in paraffin and stained with Hematoxylin& Eosin. Tumours were classified according to WHO classification (2014). Histochemistry was done whereverrequired. Results:A total of 116 ovarian neoplasms were studied during this period. Majority were benign tumours (91.4%), followed by malignant (6.9%) and borderline tumours (1.7%). Epithelial tumors comprise about 78.4%, followed by Germ cell tumors (15.5%) and Sex cord-stromal tumors 6%. Serous cystadenoma was the commonest benign tumor and Adult granulosa cell tumour was the commonest malignant ovarian tumour. Conclusion:The prognosis and varying therapeutic strategies of ovarian tumours necessitate an accurate pathological evaluation. Histopathological study is still the gold standard in diagnosing most of these tumours
International Journal of Gynecological Cancer, 2013
Objective: Concurrent presence of endometrial hyperplasia or cancer in patients with granulosa cell tumors (GCTs) is common, with reported incidences of 25.6% to 65.5%. Consequently, bilateral salpingo-oophorectomy and hysterectomy is usually recommended in patients with a GCT, but this remains debatable. Our aim was to evaluate the need for hysterectomy in patients with GCTs by studying the incidence of pathologically confirmed endometrial abnormalities at the time of diagnosis of GCT and during follow-up. Materials/Methods: All cases of GCT between 1991 and 2012 were evaluated for endometrial pathology using the Dutch nationwide network and registry of histopathology and cytopathology (PALGA). Results: A total of 1031 cases of GCT were identified at a mean T SD age of 55 T 17 years. The incidence of GCTs in the period 1991Y2012 was 0.61 per 100,000 women per year. Concurrent endometrial cancer at the time of diagnosis of GCT was found in 58 patients (5.9%) and endometrial hyperplasia in 251 patients (25.5%), including complex hyperplasia in 89 patients (9.1%) and simple hyperplasia in 162 patients (16.5%). Long-term follow-up of 490 patients (47.5%) without a hysterectomy showed that endometrial abnormalities were found in 10 patients (2.0%) of which 2 had endometrial cancer. Interestingly, 8 (80%) of the 10 patients with endometrial abnormalities had recurrent GCT at the time of diagnosis of endometrial hyperplasia or cancer. Conclusions: Our data suggest that after surgical removal of GCT, development of an endometrial abnormality, especially cancer, is very rare. Therefore, hysterectomy is not recommended in patients with a GCT without endometrial abnormalities at the time of diagnosis.
Granulosa Cell Tumors of the Ovary: A Retrospective Tertiary Center Experience
Journal of clinical obstetrics & gynecology, 2021
Granulosa cell tumor (GCT) is a rare ovarian malignancy originating from sex cord-stromal cells. Sex cord stromal tumors account for 5-8% of all ovarian malignancies. 1 GCTs, which constitute approximately 70% of sex cord stromal ovarian tumors, are seen in 0.4-1.7 per 100,000 women. They are divided into 2 subgroups as juvenile (5%) and adult (95%) tumors based on their clinical presentation and histologic characteristics. The only clinically proven prognostic factor regarding recurrence is stage. However, patient age, tumor size, presence of intraperitoneal disease and the scope of the operation also play a role in prognosis. 2 Histological prognostic factors include nuclear atypia and mitosis. 3 Average recurrence is 5 years after surgery for the primary tumor. However, cases recurring even 20-30 years after the initial diagnosis have been reported in the literature. 4 Only 2% of GCT cases are bilateral, and most cases are diagnosed at Stage 1. Synchronous GCT has also been reported very rarely. They are usually lowgrade tumors with good prognosis. The most common presentation includes abdominal pain and distention. 5 Also they can secrete estrogen. Endometrial thickness should be evaluated with transvaginal ultrasound
Histopathological patterns of ovarian lesions: A study of 161 cases
BIOCELL, 2019
Ovarian lesions are commonly encountered pathologies that cannot be categorized clinicoradiologically. Definite diagnosis is of great importance for therapeutic and prognostic purposes. Histopathology gives accurate diagnosis in most cases. Few cases need supportive tests like immunohistochemistry. Objective: to study the histomorphological diversity of ovarian lesions, their age and location in North of Iraq (Mosul and Duhok). Patients and methods: In the period extended from January 2008 to December 2011, 161 cases of ovarian lesions were collected from pathology departments in Azadi General Hospital "Duhok" and Al-Jamhori Teaching Hospital "Mosul". Automated tissue processor was used for histologic study and Streptavidin-biotin method on paraffin sections was applied for immunohistochemistry. Result: There was a wide age range, most being in the third decade. The right ovaries were more common involved than the left. Histologically, 58 (36%) cases were non-neoplastic and 103 were neoplastic including 90 (55.9%) benign and 9 (5.6%) malignant tumors. The remaining 4 (2.4%) cases comprised borderline serous cystadenoma. Conclusion: Most ovarian lesions were functional non-neoplastic followed by benign neoplastic. Apart from few cases, diagnosis was merely histological without any ancillary test.