High disease activity is associated with high disease damage in an Iranian inception cohort of patients with lupus nephritis (original) (raw)

Clinical and experimental rheumatology

Abstract

This paper aims to determine disease activity and damage in patients with lupus nephritis (LN) and to evaluate the correlation among these domains and sociodemographic features. This study was carried out on 71 lupus patients who were candidate for kidney biopsy due to their clinical renal manifestations. Clinical and sociodemographic data were collected and the Systemic Lupus Erythaematosus Disease Activity Index (SLEDAI-2K updated version), European Consensus Lupus Activity Measurement (ECLAM) and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) were assessed after 10 days of admission, the day prior to performing renal biopsy. Sixty-five females (91.5%) and six males (8.5%) were studied. Their age was 24 (21-32) yr and disease duration was 1.5 (0.8-4) yr (median [IQR]). SLEDAI-2K, ECLAM and SDI scores were 25.5±12.3, 6.21±2.45, 2.0±2.3 (mean±SD) respectively. A great relationship between SLEDAI-2K and ECLAM (r=0.827, p<0.00...

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