A Review of Penile Cancer (original) (raw)

Penile cancer: a case series in two tertiary care teaching hospitals with review of literature

Sri Lanka Journal of Surgery, 2017

Introduction Carcinoma of penis is a very rare disease most commonly affecting elderly men. This rare disease can have terrible and horrifying consequences on the social and emotional life of patients as well as their families. The objective of our case series is to describe the sociodemographic and clinical features, the standard investigations and treatment protocols and follow up of patients who presented to our hospitals. Methodology This is a prospective study of fourteen patients admitted in two tertiary care teaching institutions of Kolkata between January 2013 to December 2015 with a histopathological diagnosis of penile cancer. Results and discussion Age of patients varied between 45 to 82 years. Duration of disease varied between 3-13 months. Nine patients had palpable inguinal lymphadenopathy and 2 patients had liver metastases. Eight patients underwent partial amputation of penis and 4 patients underwent total amputation. Conclusion Penile cancer is a rare disease with devastating consequences. Patients often present late and the primary surgical treatment is often disfiguring. Aggressive surgical treatment of the primary disease and groin remains the cornerstone in the management of high-risk cases.

Penile cancer: a case for guidelines

Annals of the Royal College of Surgeons of England, 2001

Aspects of the management of penile cancer remain controversial. In the management of early T1 N0 disease, treatments are divided between amputation and a variety of penis conserving techniques (PCT); local excision, laser techniques, chemotherapy and radiotherapy. We report on a retrospective series of patients with penile cancer. Thirty-seven patients were diagnosed between 1987-1996. All patients records were retrieved. Data recorded included TNM stage, histological grade and treatment. The end-points were death, nodal progression and local recurrence. Median survivor follow-up of 42 months was obtained. Twenty-six patients (70%) presented with T1 disease, 7 (19%) T2 and 4 (11%) T3 or T4. Inguinal nodal disease was seen in 11 (30%). The mean age was 63 years. Overall, 13 penile amputations were performed, 13 underwent radiotherapy, 6 were locally excised in combination with radiotherapy and 3 underwent local excision alone. Two patients were unsuitable for treatment. Of the total...

Penile Cancer: Epidemiology and Treatment

Current Oncology Reports, 2011

Penile cancer is an aggressive disease, with major psychological and social impact. The etiological factors are poor genital hygiene, the presence of phimosis, viral infection, ultraviolet radiation, smoking, balanitis xerotic obliterans, and chronic lichen. Identifying prognostic factors is important to select patients at risk for lymph node metastasis and avoid unneeded lymphadenectomy. The presence of lymph node metastasis is currently the strongest prognostic factor but its evaluation is imperfect using clinical and laboratorial methods. The treatment for invasive penile cancer is based on the treatment of primary tumor, usually with amputation and regional lymphadenectomy, treatments that have a high morbidity rate.

Clinical Characteristics and Difficulties in the Management of Cancer of the Penis

Open Journal of Urology, 2021

Introduction: Penile cancer is a rare primary malignancy that occurs in patients in their 60s and 70s. The aim of the study was to describe the anatomical aspects of penile cancer and to report the difficulties of its management. Materials and Methods: This was a retrospective descriptive study of patients with penile tumors from January 2007 to December 2019. Patients of sexual age with an ulcerated lesion of the penis, who came to our department and whose clinical and paraclinical workup led to the diagnosis of penile cancer, were included. The variables studied were clinical, paraclinical and therapeutic. Results: In 12 years, we diagnosed and managed 8 patients with penile cancer, an incidence of 0.7 per year. The reason for consultation was the chronic ulcerating wound of the penis with a "cauliflower" aspect. The first medical consultation was late (n = 8) after a long latency period lost to traditional healers. The lesion was located in the glans penis (n = 6) and/or in the corpus cavernosum (n = 2). Histological analysis of the cores concluded to a squamous cell carcinoma. Patients were classified as T2N+M+ (n = 3) and T2N0M0 (n = 5). One patient had accepted partial amputation of the penis. Conclusion: Penile cancer is a rare tumor. Partial amputation of the penis is the only alternative in our practice context, an alternative often refuted.

Penile Squamous Cell Carcinoma in a 95-Year-Old Patient: Case Report and Literature Review

Cureus

Penile cancer is a rare disease. Delay in diagnosis and treatment frequently occurs and high morbidity can be observed in affected patients. The management is based on surgical resection. The inguinal node staging depends on the disease-related risk. We herein report a 95-year-old male patient, with a history of a right inguinal hernia, surgically treated. He presented with a swollen painful glans penis. The glans biopsy identified a moderately differentiated invasive squamous cell carcinoma. We have performed a complete penectomy with a bilateral inguinal lymph node dissection. The patient is currently receiving adjuvant chemotherapy based on cisplatin Categories: Urology, Oncology

Penile tumours: a review

Journal of the European Academy of Dermatology and Venereology, 2014

Penile tumours are an important problem of male health affecting physical, mental and sexual health. Penile tumours can be subdivided into benign and malignant lesions. Their knowledge is important to prevent mutilating surgery in benign lesions. On the other hand, early recognition of malignancies is important for improved prognosis, and preservation of function. The most important tumour by epidemiology and prognosis is penile cancer. In contrast, malignant melanoma, sarcomas and lymphomas are rare. Clinical symptoms, histopathology and treatment options are discussed. Best possible treatment needs an interdisciplinary approach.

Invasive Penile Carcinoma: A Review

Dermatologic Surgery, 2004

BACKGROUND. Penile carcinoma is an invasive epithelial tumor that may arise from penile skin or mucosa. OBJECTIVE. To review the pathogenesis and the clinical and histopathologic features of invasive penile carcinomas, with emphasis on current guidelines for their diagnosis and treatment. METHODS. Information available from the authors' clinical experience, review articles, case reports, clinical trials, and in vitro research studies identified from a computerized literature search on MEDLINE database and from Meetings' Abstract Books, including those from non-English literature, was considered. RESULTS. Penile cancer may develop de novo or in association with underlying factors. Conditions predisposing to the development of penile cancer are delineated. The diagnosis should be suspected by clinical findings and must be confirmed histo-

Conservative treatment of penile carcinoma - a retrospective study of 10 years

Anais Brasileiros de Dermatologia, 2013

Conservative treatment of penile squamous cell carcinoma has been advocated as a method of choice for tumours at early stages. Thirty patients with a mean age of 63.2 years were treated with CO2 laser ablation, radical local excision with preputial flap, direct closure or healing by secondary intention, circumcision alone or associated with CO2 laser and topical imiquimod. Sixteen patients had local recurrence. Partial penectomy was necessary in 3 patients. Conservative treatments of penile squamous cell carcinoma in early stages (< T1a) do not seem to compromise the survival rate, so it may be advisable for this subset of patients.