P.93 Sentinel node biopsy and subclinical lymphnode metastasis in patients with oral SCC, T1-T2, NO, MO (original) (raw)
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Lymphoid Malignancies: Oral Manifestation and Considerations
2019
Lymphoid tissues are distinguished anatomic structure in body responsible for host immune response. Malignancy of the lymphocyte cell line takes up about 14% of all head-neck malignancies. Due its manifestations resembling several non-malignant lesions of oral cavity oral malignant lymphomas are often misdiagnosed. The misdiagnosis may also result in diffusion of tumour when treated with invasive dental procedures. Hence this review was under taken to report the oral manifestations of lymphoid malignancies. Anisha Yaji1*, Shesha Prasad R2, Usha Jambunath2, Rekha Jayram2 and Anuradha Pai2 2Department of Oral Medicine and Radiology, The Oxford Dental College, India 1Department of Dentistry, Division of Oral Medicine and Radiology, Shri Krishna Sevashrama Hospital, India Anisha Yaji, et al., Journal of Hematology & Multiple Myeloma Remedy Publications LLC. 2019 | Volume 4 | Issue 1 | Article 1022 2 Mature B-cell neoplasms Chronic lymphocytic leukemia/small lymphocytic lymphoma Monoclon...
Oral manifestations of lymphoma: a systematic review
ecancermedicalscience, 2016
Lymphoma is a malignant disease with two forms: Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Non-Hodgkin's lymphoma is diagnosed in extranodal sites in 40% of cases, and the head and neck region is the second most affected, with an incidence of 11-33%, while HL has a very low incidence in extranodal sites (1-4%). The aim of this study was to identify the oral manifestations of lymphoma through a systematic literature review, which we conducted using the PubMed, Lilacs, Embase, and Cochrane Library databases. We found 1456 articles, from which we selected 73. Among the intraoral findings, the most frequent were ulcerations, pain, swelling, and tooth mobility, while the extraoral findings included facial asymmetry and cervical, submandibular, and submental lymphadenopathy. Among the few studies reporting imaging findings, the most cited lesions included hypodense lesions with diffuse boundaries, bone resorptions, and tooth displacements. The publications reviewed highlight gaps in the areas of early detection, diagnosis, and proper treatment.
Oral Malignant Non-Hodgkin Lymphoma: A Retrospective Single-Center Study
International Journal of Environmental Research and Public Health, 2022
This study aimed to retrospectively evaluate the incidence of oral non-Hodgkin lymphoma (NHL) in patients referred to the Academic Hospital of the Magna Graecia University of Catanzaro from 2002 to 2020. A retrospective single-center study was performed. Patients with a histologically confirmed diagnosis of oral NHL were included. Demographic data and clinical parameters were digitally recorded, focusing on the NHL-specific localization and symptomatology. The study sample was evaluated by analyzing descriptive statistics with absolute and relative frequencies. A total of 26 patients with intraoral NHL were identified with a progressive increase in NHL occurrence during the observation period. Clinical manifestations included swelling/mass (80.7%), eventually associated with pain and ulcerations. The most common localizations were in soft tissues: buccal mucosa (38.4%), tongue (19.2%), gingiva (11.5%), cheek (11.5%). Oral NHL is rare. Clinical manifestations were unspecific, so a mi...
European Archives of Oto-Rhino-Laryngology, 2019
Purpose We aimed to investigate the frequency and clinicopathological features of oral NHL in our institution as well as to compare the data gathered from other oral pathology and general pathology services published in the literature. Methods Clinical records of patients diagnosed with NHL exclusively affecting the oral cavity were reviewed from 1997 to 2017. Additionally, a review of the literature over a 20-year period was conducted aiming to examine articles on oral NHLs. Results Oral NHLs represented 0.1% (n = 98) of the total number of biopsies (68,229) received during the period evaluated (1997-2017). The mean age at the diagnosis was 47 years. Most patients were white (67.3%). A nodular lesion was the most frequent presentation (54.9%) and pain was described in 47.1% of the cases. The most common diagnosis was diffuse large B cell lymphoma (42%) followed by plasmablastic lymphoma (24%). Only 19 articles were included in the review of the literature. Conclusions Although NHLs are rare in the oral cavity, clinicians and surgeons have an important role in promptly diagnosing lymphomatous lesions to refer the patient to a proper treatment.
Oral lesions and lymphoproliferative disorders
Journal of Oncology, 2010
Lymphoproliferative disorders are heterogeneous malignancy characterized by the expansion of a lymphoid clone more or less differentiated. At the level of the oral cavity, the lymphoproliferative disorder can occur in various ways, most commonly as lymphoid lesions with extranodal externalization, but sometimes, oral lesions may represent a localization of a disease spread. With regard to the primary localizations of lymphoproliferative disorders, a careful examination of the head and neck, oral, and oropharyngeal area is necessary in order to identify suspicious lesions, and their early detection results in a better prognosis for the patient. Numerous complications have been described and frequently found at oral level, due to pathology or different therapeutic strategies. These complications require precise diagnosis and measures to oral health care. In all this, oral pathologists, as well as dental practitioners, have a central role in the treatment and long-term monitoring of these patients.
Oral Lymphoma: A Report of Two Contrasting Cases
Journal of the Irish Dental Association
Lymphoma presenting in extra-nodal sites is less common and its presentation in the oral cavity can often be an indicator of widespread disease elsewhere in the body. We present two cases of non-Hodgkin's lymphoma of differing subtypes, presentation, severity and prognosis to indicate the heterogeneity of the condition. These cases illustrate the role of primary care clinicians, including general dental practitioners (GDPs), in the diagnosis of lymphoma affecting the oral cavity. Case 1 A 55-year-old male initially presented to the oral and maxillofacial surgery (OMFS) emergency clinic with multiple, painful intra-oral gingival swellings in the upper left, upper right and lower left quadrants following an urgent referral from his general medical practitioner (GMP). The patient had initially been examined by his GDP, who had excluded dental aetiology. Oral lymphoma: a report of two contrasting cases Précis We highlight the varying manifestations of lymphoma in the oral cavity by presenting two contrasting cases. The journey from referral to diagnosis and management is discussed.
Indian Journal of Medical and Paediatric Oncology, 2011
Background: Non-Hodgkin's lymphomas (NHL) have a great tendency to affect organs and tissues that do not ordinarily contain lymphoid cells. Involvement of the oral cavity by NHL is very rare. Materials and Methods: Retrospective analysis was carried out by chart review of patients who presented to our hospital between 1990 and 2008. All those patients whose histopathology at our hospital was confirmed as lymphoma were included. Results: Although we register nearly 2000 new oral cancers every year, most of which are squamous cell cancers, we could trace only 15 cases of oral lymphoma in the last 18 years. Of these, hard palate and alveolus were most common sites (5 each). The median age at presentation was 42.6 years. A vast majority (12/15) were NHL. Most patients (70%) reported with painless progressive swelling without systemic signs, such as fever, weight loss, and so on. Only 2 patients were HIV positive. Nearly two thirds received combinations of CT and RT. Cyclophosphamide, hydroxydaunorubicin, oncovin (vincristine), prednisolone regime was the most common regime offered (12/15). Most of them (67%) had good response to 6 cycles of CT that was followed by RT. 10/15 patients completed treatment. Follow-up data of more than 2 years of follow-up was present in 11/15 patients. With median follow-up of 27 months, 5 were disease free, 5 died, and 1 controlled following 2nd line of CT, 2 were lost to followup and 2 were alive with disease. Discussion: Head and neck lymphoma is the second most common region for extranodal lymphoma. The nasopharynx, tonsils, and base tongue are most often involved. Unlike the western world, oral cavity involvement is extremely rare. Interestingly, only 2 patients tested positive for HIV and most were young patients. Oral lymphoma may mimic benign oral conditions that often lead to misdiagnosis. Conclusion: Although oral cavity may be the preferred site of NHL in immunocompromised patients it does occur in immunocompetent patients as well. Isolated oral lymphoma is extremely rare and from our data we can say that oral NHL in Indian sub population is more aggressive compared with western literature.
Malignant Lymphomas in the Head and Neck Region - a Retrospective, Single-Center Study over 41 Years
International Journal of Medical Sciences, 2015
Objectives: Non-Hodgkin lymphomas are malignant neoplastic proliferations of the immune system that can manifest as nodal or extranodal lymphomas. The aim of this study was to retrospectively investigate the site of occurrence of lymphomas in the head and neck area and to analyze the typical symptoms of patients who presented at an oral and maxillofacial surgical department. Material and Methods: All patient files from1971 until 2012 from an Oral and Maxillofacial Surgery of a University were analyzed for the diagnosis non-Hodgkin lymphoma. Epidemiologic data and data regarding the localization of the malignant lymphoma were evaluated. Results: 62 patients, 34 women and 28 men with a non-Hodgkin lymphoma in the head and neck area were treated in the 41 years analyzed. In 87% of the cases the lymphoma belonged to B-cell and in 12% to the T-cell lineage. The average age at the time of diagnosis was 67 years for women (n=34) and 56 years for men. With 22 patients each, the non-Hodgkin lymphoma was localized in either the soft tissues or osseous structures. In the remaining 18 cases, multiple structures were affected. In 33 patients no accompanying nodal manifestation was noticed. In 33 cases the lymphoma was located in the oral cavity. The most common symptoms were swelling (97%), pain (40%) and the existence of an ulcer (11%). Conclusion: In the present study more than 50% of the lymphomas were located in the oral cavity. Due to the unspecific symptoms, a histopathological verification of the diagnosis is crucial.