A Ratiometric Tetrazolylpyridine-Based “Turn-On” Fluorescent Chemosensor for Zinc(II) Ion in Aqueous Media (original) (raw)
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Analytical and Bioanalytical Chemistry, 2007
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A synthetic fluorescent sensor (sensor 1) is developed using boron-dipyrromethene as a fluorophore and phenoxo-bridged dipicolylamine as a receptor. Sensor 1 shows a significant enhancement of fluorescent intensity and a high selectivity for Zn 2þ over various metal cations. The electrochemical study provides a rationale for the fluorescence turn-on of sensor 1 upon complexation with Zn 2þ by the blocking of the photo-induced electron transfer mechanism. Sensor 1 can be used to image Zn 2þ in A549 cells.
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2017
Reported herein the synthesis, characterization and biologically important zinc ion binding propensity of a weakly fluorescent chemosensor, 4-methyl-2,6-bis((E)-(2-(4-phenylthiazol-2-yl)hydrazono)methyl)phenol (1). (1)H NMR spectroscopic titration experiment reveals the binding knack of 1 to the essential Zn(2+). The photo-physical studies of 1 exhibit an enhancement in the fluorescence by several folds upon binding with the zinc ions attributed to PET-off process, with a binding constant value of 5.22×10(3)M(-1). 1 exhibits an excellent detection range for Zn(2+) with lower detection limit value of 2.31×10(-8)M. The selectivity of 1 was studied with various mono and divalent metal cations and it was observed that most cations either quenches the fluorescence or remains unchanged except for Cd(2+), which shows a slight enhancement in fluorescence intensity of 1. The ratiometric displacement of Cd(2+) ions by Zn(2+) ions shows an excellent selectivity towards in-situ detection of Zn(...
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A hydrophilic bis(1,2,3-triazolyl)fluorene derivative was synthesized as a multiphoton absorbing, zinc ion sensing fluorescent probe. The fluorescence response was approximately five-fold greater in presence of Zn 2+ , resulting in a large binding constant (10 9 ) for a 1:2 ligand to zinc complex. A four-fold increase in the two-photon absorption cross section was achieved upon binding Zn 2+ . In vitro two-photon fluorescence microscopy imaging revealed a significant fluorescence increase upon introduction of Zn 2+ into HeLa cells and reversible Zn 2+ binding, demonstrating the potential of this probe for zinc ion sensing.