Theoretical study on parallel differentiation of memory T cell (original) (raw)

Acta Biochimica et Biophysica Sinica

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A theoretical study on tertiary immune response

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Hkkjro"kZ ds if'peh Hkkx es a vofLFkr ikS jkf.kd rhFkZ *Dr Krishna Devi if'peh Hkkjr ds ikS jkf.kd rhFkks ± ds vUrxZ r xq tjkr] dkfB;kokM+ ] eq EcbZ iz ns 'k ds ikS jkf.kd rhFkZ 'kkfey ga S A bl [k.M ds dq N Hkkxks a es a ejkBh cks yh tkrh gS A 'ks "k iz k;% iw js Hkkx dh Hkk"kk xq tjkrh gS ;|fi xq tjkrh dh viuh fyfi gS fQj Hkh og ns oukxjh fyfi ls cgq r feyrh&tq yrh gS A fgUnh bl iw js Hkkx es a le> yh tkrh gS vkS j ftls fgUnh Hkk"k&Hkk"kh le> lds ,s lh fgUnh iz k;% lkekU; O;fä Hkh cks y ys rs gS a A lks es 'oj rhFkZ ¼iz Hkkl½ % lkS jk"Vª ¼xq tjkr½ ds dkfB;kokM+ {ks = es a ,s frgkfld iz Hkkl rhFkZ vofLFkr gS A tgk¡ lks eukFk dk iz fl) efUnj gS A lks eukFk vukfn rhFkZ gS A Hkxoku 'ka dj ds lq iz fl) 12 T;ks frfyZ ³xks a es a lks eukFk T;ks frfyZ ³x dk iz Fke LFkku gS A ;g iz Hkkl {ks = ydq yh'k ik'kq ir er ds 'kS oks a dk ds Unz LFky jgk gS A blds ikl gh Hkxoku Jhd".k ds pj.k es a tjk uked O;k?k dk ck.k yxk FkkA bl iz dkj ;s LFkku 'kS o] oS ".ko nks uks a dk gh egkrhFkZ gS A dkyØe ls ;gk¡ ¡ vkrrkf;;ks a ds vus d vkØe.k gq , vkS j lks eukFk efUnj vus d ckj fxjk rFkk cuk gS A bl LFkku dks os jkcy] lks eukFkikV.k] iz Hkkl ;k iz HkklikV.k Hkh dgrs gS a A iq jk.kks a es a iz Hkkl iz Hkkl rhFkZ dk cM+ k gh mRd"V o.kZ u feyrk gS A iz Hkkl rhFkZ dks LoxZ ds leku ekuk x;k gS A iz Hkkl dh ifjØek djus ls iFoh dh ifjØek dk Qy feyrk gS A eu 'kq ) gks tkrk gS vkS j euq "; ds ejus ij LoxZ yks x dh iz kfIr gks rh gS A 2 dgrs gS a fd lks eukFk es a egkeR;q ¥t; dk tki djus ls euq "; ds leLr iki u"V gks tkrs gS a A vEck th 'kfDrihB ¼iz Hkkl½ % xq tjkr jkT; ds fxjukj ioZ r ds iz Fke f'k[kj ij ns oh vEck th dk fo'kky efUnj gS A ^vEck* th dks ^vfEcdk* ds uke ls Hkh lEcks fèkr fd;k tkrk gS A vEck th ds bl rhFkZ dks 'kfäihB ds :i es a ekU;rk iz kIr gS A bl rhFkZ LFkku ij ns oh lrh ds ns g dk ^mnj* Hkkx fxjk FkkA ;gk¡ dh 'kfä ^pUnz Hkkxk* vkS j HkS jo ^oØrq .M* gS a A 3 dq N xz UFkks a ds vuq lkj vEckth ¼iz Hkkl½ 'kfäihB es a iq "djkorh ns oh dk LFkku gS A vEckth rhFkZ ds lehi fLFkr yks xks a ds vuq lkj pUnz Hkkxk ,oa iq "djkorh egkek;k vEckns oh th ds gh vU; uke gS a A ikS jkf.kd dFkk ds vuq lkj xq tjkr ds vcq Z nkj.;{ks = 5 es a ioZ r f'k[kj ij ns oh lrh ds 'ko ds ân; dk ,d Hkkx fxjk Fkk] mlh v³x dh vkjkèkuk bl LFky ij vkjklq jh vfEcdk ns oh th ds uke ls gks rh gS A iq jk.kks a es a fooj.k feyrk gS fd ukjk;.k ds pØ ls dVdj ns oh lrh ds ns g ds va x iFkd~ gks dj Hkw ry ij fxjs vkS j ik"kk.ke; gks x;s A ;gk¡ lrh ds ns g ds va x fxjs og LFky egkrhFkZ vkS j eq fä{ks = 'kfDrihB dgyk;s A ;gh rhFkZ LFkku ns orkvks a ds fy;s nq yZ Hk iz ns 'k cu x;s A ek¡ vfEcdk ¼vkjkiq jh½ th dks rhuks a le; rhu iz dkj ds oL= iguk;s tkrs gS a A ftlls ns oh iz kr% ^ckyk* nks igj dks ^;q ok* ,oa lka ;dky dks ^o)k* ds :i es a fn[kk;h ns rh gS A okLro es a ek¡ vfEcdk th ;gk¡ dks bZ ew frZ ugha gS A ek¡ dks ftl :i es a ns [kks xs og mlh :i es a fn[kkbZ ns xhA ;gk¡ ,d vkys es a olz ky³dkj ls bl iz dkj Ükà ³xkj fd;k tkrk gS fd fla gij cS Bh Hkokuh ds n'kZ u gks rs gS a A efUnj ds ihNs ekuljks oj uked rkykc Hkh gS tks cgq r ifo= ekuk tkrk gS A bles a Luku djus dk cM+ k gh iq .;kRe ekgkRE; crk;k x;k gS A rhFkZ ;k=h dks bl LFky ij cz ãp;Z iw oZ d jguk iM+ rk gS A bl LFkku ij cz ãp;Z ds fu;e dks Hk³x djus ls vfu"V gks rk gS A iz Hkkl 'kfäihB dk vkèkq fud lekt es a cM+ k gh ekgkRE; crk;k x;k gS A bl rhFkZ LFkku ds n'kZ uks a ds fy;s ns 'k&fons 'k ls yk[kks a J)kyq vkrs gS a A gtkjks a &yk[kks a euq ";ks a dh dkeuk,a ek¡ vfEcdk dh dìk ls iw jh gks tkrh gS A bl LFkku ij HkDrks a dh ek¡ vEcs ds iz fr cM+ h vkLFkk o fo'okl gS A bl rhFkZ es a ,d ckj vkus ls ijyks d es a eks {k dh iz kfIr gks rh gS A vkcw rhFkZ % vkcw rhFkZ vgenkckn&fnYyh vkcw jks M LVs 'ku ls 17 fdyks ehVj dh nw jh ij vofLFkr gS A vkcw mÙke rhFkZ gS ;g rhFkZ LFkku ,d ioZ r ds :i es a vofLFkr gS A vkcw rhFkZ LFkku dks orZ eku le; es a ekÅa V vkcw ds uke ls igpkuk tkrk gS A vkcw ioZ r 14 ehy yEck vkS j nks ls pkj ehy pkS M+ k Hkh gS A tuJq fr;ks a ds vuq lkj vkcw uke fgeky; ds iq = vcq Z n ds uke ij iM+ k FkkA vcq Z n cgq r gh iz fl) ,oa 'kfä'kkyh lk¡ i Fkk ftlus ,d xgjh [kkbZ es a Hkxoku f'ko ds ifo= okgu ua nh cS y dh tku cpkbZ FkhA

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