Isolation, identification, bioprocessing and characterization of secondary metabolites for its antimicrobial and genotoxicity from the soil screened microorganism (original) (raw)

The paper investigates the isolation, identification, bioprocessing, and characterization of secondary metabolites from soil-derived Actinomycetes, focusing on their antimicrobial and genotoxic properties. Following the screening of 77 soil samples, two strains demonstrating significant antimicrobial activity, identified as Bacillus subtilis (RRK1) and Staphylococcus aureus (RRK2), were selected for further evaluation. Various extraction methods yielded significant quantities of bioactive compounds, showing effective antimicrobial action against a range of pathogens. Additionally, genotoxicity studies suggested protective DNA effects of the compounds, addressing the critical concern of antibiotic resistance.