313371 Wefold: A Collaborative Protein Structure Prediction Experiment (original) (raw)

Abstract

The protein structure prediction problem continues to elude scientists. Even though many new methods have been introduced, certain classes of prediction targets such as free modeling targets remain a challenge based on blind predictions in the several previous Critical Assessment of Techniques for Protein Structure Prediction (CASP) experiments [1]. To meet this challenge, a large-scale collaborative effort called WeFold was undertaken by thirteen labs, each with their own specialties and approaches in addressing the problem. In this talk, we will present the different methods or branches collaboratively designed and tested during the WeFold experiment, as well as their predictive ability, outcomes, and lessons learned. Independent branches involved in the collaborative effort yielded several high-ranking predictions among all group and method submissions in CASP10 for human, free modeling (template free), and refinement targets. Remarkably, two WeFold methods were able to produce t...

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