Association of Vitamin D With Insulin Resistance and -Cell Dysfunction in Subjects at Risk for Type 2 Diabetes: Response to Muscogiuri et al (original) (raw)
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Diabetes …, 2010
Objective: To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta (β)-cell dysfunction in 712 subjects at risk for type 2 diabetes. Research Design and Methods: Serum 25(OH)D was determined using a chemiluminescence immunoassay. Insulin sensitivity/resistance were measured using the Matsuda index (IS OGTT) and HOMA-IR. Beta-cell function was determined using both the insulinogenic index divided by HOMA-IR (IGI/IR) and the Insulin Secretion Sensitivity Index-2 (ISSI-2). Results: Linear regression analyses indicated independent associations of 25(OH)D with IS OGTT and HOMA-IR (β=0.004, p=0.0003 and β=-0.003, p=0.0072 respectively), and with IGI/IR and ISSI-2 (β=0.004, p=0.0286 and β=0.003, p=0.0011 respectively), after adjusting for sociodemographics, physical activity, supplement use, parathyroid hormone and BMI. Conclusions: Vitamin D may play a role in the pathogenesis of type 2 diabetes, as 25(OH)D concentration was independently associated with both insulin sensitivity and β-cell function among individuals at risk of type 2 diabetes.
Vitamin D Deficiency and Insulin Resistance in Normal and Type 2 Diabetes Subjects
Vitamin D is recognized to serve a wide range of biological functions. The presence of vitamin D receptors on different tissues explains it's diversity of actions. Reduced levels of vitamin D is associated with insulin resistance and increased diabetes risk. The study included 50 normal healthy individuals and 49 type 2 diabetes subjects. Fasting blood glucose, total cholesterol, triglyc-erides, HDLc, fasting insulin, parathyroid hormone, calcium , albumin and Homeostasis model for assessment of insulin resistance (HOMAIR) were measured in all the study participants. Type 2 diabetes subjects were divided into group 1 with 25 hydroxy vitamin D (25(OH)D) B20 ng/ml and group 2 with 25(OH)D [20 ng/ml. By the results of this study, the mean 25(OH)D level was low (20.09 ng/ml) in type 2 diabetes compared to controls (23.89 ng/ml) and the p value was 0.02. The estimated insulin resistance by HOMAIR was more in group 1 than in group 2 of diabetes with p value of 0.037. The Pearson's correlation-coefficient was negative for 25(OH)D and insulin in type 2 diabetes (r =-0.294), 25(OH)D was negatively correlated with HOMAIR in total subjects. Type 2 diabetes subjects had reduced levels of vitamin D than normal individuals. The insulin resistance was more in vitamin D deficiency state. Hence vitamin D has a role in glucose metabolism, deficiency can result in insulin resistance and diabetes.
Nutrients
Recent evidence has revealed anti-inflammatory properties of vitamin D as well as extra-skeletal activity. In this context, vitamin D seems to be involved in infections, autoimmune diseases, cardiometabolic diseases, and cancer development. In recent years, the relationship between vitamin D and insulin resistance has been a topic of growing interest. Low 25-hydroxyvitamin D (25(OH)D) levels appear to be associated with most of the insulin resistance disorders described to date. In fact, vitamin D deficiency may be one of the factors accelerating the development of insulin resistance. Vitamin D deficiency is a common problem in the population and may be associated with the pathogenesis of diseases related to insulin resistance, such as obesity, diabetes, metabolic syndrome (MS) and polycystic ovary syndrome (PCOS). An important question is the identification of 25(OH)D levels capable of generating an effect on insulin resistance, glucose metabolism and to decrease the risk of develo...
Nutrients
Vitamin D has been implicated in the regulation of glucose metabolism and insulin resistance. We designed this study to provide evidence that insulin resistance is dependent on the concentration of vitamin D in the body. Forty observational studies of both type 2 diabetes mellitus patients and healthy subjects were included in this meta-analysis. Related articles were searched from Embase, PubMed, and Medline through January 2021. Filters for search were used to obtain more focused results. We used Comprehensive Meta-Analysis Version 3 for the construction of forest plots. RevMan software version 5.3 was used to build the risk of bias tables and summary plots. The observational studies included in this systematic review and meta-analysis showed an inverse relationship of insulin resistance with the status of vitamin D both in non-diabetic (r = −0.188; 95% CI = −0.141 to −0.234; p = 0.000) and diabetic (r = −0.255; 95% CI = −0.392 to −0.107, p = 0.001) populations. From the meta-anal...
Association of vitamin D deficiency with insulin resistance in middle-aged type 2 diabetics
Clinica Chimica Acta, 2019
Background: Vitamin D deficiency contributes to the pathophysiology of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). We investigated the association of 25-hydroxyvitamin D [25(OH)D] with IR and β-cell function in middle-aged participants. Methods: We enrolled 90 controls and 90 T2DM patients of both genders aged 30-50 years. Serum 25(OH)D, fasting plasma insulin (FPI), fasting plasma glucose (FPG), HbA1c, and lipid profile were measured by standard methods. Insulin resistance and sensitivity were assessed by triglyceride glucose (TyG) index, homeostatic model assessment (HOMAIR), quantitative insulin sensitivity check index (QUICKI), and β-cell function by HOMA-B. Results: 25(OH)D deficiency was reported as 40% in control and 70% in T2DM patients. 25(OH)D concentration was positively associated with age, blood pressure, T2DM duration, FPG, HbA1c, TyG index, and HOMA-IR and negatively associated with HOMA-B and QUICKI among all the participants (p ≤.001). Participants with severe 25(OH)D deficiency (< 10 ng/ml) were 39 times higher odds of being T2DM, while, those with moderate deficiency (10-19ng/ml) and insufficiency (20-29 ng/ml) were 16 times and 13 times higher odds of being T2DM, respectively. Conclusion: Sufficient 25(OH)D concentration may lower the risk of development of IR and T2DM in middleaged control and diabetic participants.
Impact of Vitamin D Elements in Insulin Sensitivity in Type 2 Diabetes Mellitus (DM2)
Medico-Legal Update, 2021
Numerous non-skeletal diseases have been reported to be associated with vitamin D status including type2 diabetes mellitus (T2DM). Different studies provide evidence that vitamin D status as well as other elements such as vitamin D binding protein (DBP) and vitamin D receptor (VDR) may play substantial role in glucose tolerance. Present study was designed to investigate the role of vitamin D status and their elements in insulin resistance or sensitivity in T2DM patients Current study includes 84 participants of both gender (56 patients and 28 as control). Clinical samples were collected from clinically proved DM2 patients. Serum levels of insulin, FBS, VD, VDR, and DBP were measured of each subjects. Using of Homeostasis Model Assessment Insulin resistance (HOMA-IR), T2DM patients were sub grouped to insulin resistance (IR) and insulin sensitivity (IS) groups. Relations among studied factors, FBS showed significant positive and negative relation with HOMA-IR and VD3 respectively, furthermore HOMA-IR revealed significant positive relation with DBP and VDR. Also, DBP revealed significant positive relation with each of VDR and HOMA-IR. On the other hand, VD3 levels showed significant and non-significant elevation in IS group compared to C and IR group respectively, while DBP revealed significant and non-significant dropping in IS group compared to C and IR groups respectively. Levels of VDR in IS group showed significant dropping compared to C and IR groups respectively. Our study concludes that VD3 alone or with its elements play substantial role in regulation of blood sugar levels particularly related to insulin sensitivity.
Background: Some observational studies show that the consumption of vitamin D is one of the preventive methods which may potentially be useful in the reduction of diabetes type ΙΙ development, insulin resistance, impaired glucose tolerance, and metabolic syndrome. The purpose of this study was to evaluate the effect of vitamin D on insulin resistance in patients with type II diabetes. Methods: This study was conducted as a comprehensive cohort design in Qom, Iran, in 2012. The participants were 120 patients with type II diabetes of whom, 58 agreed to be randomized into two groups and 62 patients were allocated to their preferences. For randomized treatment group, a pill of vitamin D which contained 50000 units was used weekly and orally for duration of 3 months. In the control group, the placebo pill of vitamin D was prescribed by the same method. In the preferential group, patients received neither vitamin D nor placebo. The value of insulin resistance was defined as a score greate...
Relationship between insulin resistance and plasma vitamin D in adults
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 2014
A recent relationship between vitamin D deficiency and the risk of type 2 diabetes mellitus (T2DM) and insulin resistance has been established through several studies. Research suggests a correlation between serum vitamin D and glycemic status measures. The aim of this study was to investigate the relationship between the plasma vitamin D levels (25[OH]D) and the factors linked to insulin resistance in a representative sample of Canadians ranging in age from 16-79 years. Data were used from the Canadian Health Measures Survey where direct measures of health and wellness were reported from 1,928 subjects. These data were gathered from March 2007-February 2009 at 15 sites selected through a multistage sampling strategy. An inverse relationship between insulin resistance and plasma vitamin D level in both men and women was observed. This study provides additional evidence for the role of vitamin D in T2DM. If causally associated, the supplementation of vitamin D may help in preventing insulin resistance and subsequent T2DM.
The Indonesian Biomedical Journal
BACKGROUND: 25(OH)D level is correlated with insulin secretion and tissue sensitivity to insulin. Administration of vitamin D supplements may reduce tissue resistance to insulin in type 2 diabetes mellitus (T2DM), but a number of studies found conflicting results. The present study was to measure the results of administration of vitamin D supplements for 3 and 6 months regarding HbA1c, fasting blood glucose (FBG), insulin and tissue resistance to insulin in T2DM cases.METHODS: A randomized double-blind placebo-controlled trial was conducted in T2DM patients with ≤3 years duration. Subjects were randomly divided into two groups: 47 subjects received daily 5000 IU vitamin D supplementation and 47 subjects received daily placebo as control. After supplementation for 3 and 6 months, homeostatic model assessment for tissue resistance to insulin (HOMA-IR), insulin, HbA1c, and FBG were examined.RESULTS: Supplementation of daily 5000 IU vitamin D for 3 months increased 25(OH)D level in the ...