Individual methylmercury intake estimates from local seafood of the Mediterranean Sea, in Italy (original) (raw)
Related papers
Methylmercury Risks and EPA + DHA Benefits Associated with Seafood Consumption in Europe
Risk Analysis, 2010
The intake of methyl-Hg and EPA + DHA through consumption of seafood in Europe as well as the associated probability of exceeding the provisional tolerable weekly intake (PTWI) and the recommended daily intake (RDI), respectively, were estimated by combining methyl-Hg and EPA + DHA contents in the five most consumed seafood species with hypothesized consumption distributions for eight European countries, chosen on the basis of size and representative significance. Two estimators were used: plug-in (PI) and tail estimation (TE). The latter was based on the application of the extreme value theory to the intakes distribution curves. Whereas contents data were collected from own database and published scientific papers, consumption data were obtained from statistical sources of the various countries. Seafood consumption levels varied considerably between countries, from 140 in the United Kingdom to 628.5 g/(person.week) in Iceland. The main consumed species were also different between countries. The probability of exceeding the methyl-Hg PTWI ranged from 0.04% in the United Kingdom to 9.61% in Iceland. Concerning the probability of exceeding the RDI of EPA + DHA, Iceland was third, after Portugal (66.05%) and Spain (61.05%) and the United Kingdom was the last (0.32%). While TE was most accurate for small probabilities, PI yielded best estimates for larger probabilities.
Food Control, 2013
For hake, ray, and silver scabbard fish, the intake of methylmercury (methyl-Hg), selenium (Se), and eicosapentaenoic þ docosahexaenoic fatty acids (EPA þ DHA) through their consumption in Portugal and the associated probability of exceeding the provisional tolerable weekly intake (PTWI), the recommended daily allowance (RDA), and the recommended daily intake (RDI), respectively, were estimated. For this, the methyl-Hg, Se, and EPA þ DHA concentrations in the studied fish species were combined with constructed consumption scenarios for the elaboration of consumption recommendations or with a hypothesized Portuguese consumption distribution with the purpose of estimating the risk-benefit situation in Portugal.
Environmental Research, 2008
Background: Seafood is considered by toxicologists as the main source of methylmercury (MeHg), but little data is available concerning contamination of seafood and MeHg status of French frequent consumers. Objectives: The objectives were to assess food exposure and biomarker of exposure of MeHg from a group of frequent consumers of seafood. Methods: Two approaches to exposure assessment were used: the currently used food intake and the biomarker of exposure. A validated food frequency questionnaire (FFQ) was used to assess seafood consumptions for 80 products of 385 frequent consumers aged 18 and over in four French coastal areas. Seafood samples were collected in each region considering preservation methods and supply habits according to a total diet study sampling. Food samples were analyzed for MeHg. Exposure was assessed by combining consumptions with contamination data. Whole blood samples were collected from the volunteers and analyzed for MeHg. Results: The mean dietary exposure to MeHg or weekly intake (WI FFQ ) was 1.5171.17 mg/kg bw/wk. Thirty-five percent of the subjects exceed the Joint Expert Committee on Food Additives (JECFA) provisional tolerable weekly intake (PTWI), whereas the use of the biological results with the JECFA/Environmental Protection Agency (EPA) one-compartment pharmacokinetic model to calculate weekly intake (WI PKM ) shows that only 2% of subjects exceed the PTWI. The mean of the individual ratios WI FFQ /WI PKM is 4.3 and the higher the WI FFQ and the blood MeHg level, the lower is the ratio, close to 1-2. Conclusions: These analyses support the assumption that the calculated dose of methylmercury is overestimated with the FFQ-based method used in this study. Since FFQ are commonly used in risk assessments, the overestimate of dose is public health protective and this finding is somewhat reassuring from a public health point of view, especially since the JECFA or EPA have applied uncertainty factors of 3.2 or 3, respectively, to take into account the inter-individual pharmacokinetic variability. r
Exposure and risk characterization for dietary methylmercury from seafood consumption in Kuwait
The Science of the total environment, 2017
Seafood is an important source of essential nutrients; however, it can also confer health risks from methylmercury (MeHg). In this paper, we evaluate the levels of potential methylmercury exposure among Kuwaiti seafood consumers in order to support the development of dietary recommendations for fish consumption in Kuwait. Total mercury (HgT) concentration for most of the studied fish and shellfish species were on average below the 0.5μgg(-1) Codex guideline. The notable exception to this was Hamoor (Epinephelus coioides), which averaged 1.29μgg(-1) HgT and 0.55μgg(-1) MeHg. A dietary survey of 2393 households demonstrated that large quantities of fish and shellfish are commonly consumed in Kuwait (average consumption: 103gd(-1)). Most participants (53.6%) exceeded the Tolerable Daily Intake of MeHg; this percent exceedance was as high as 78% in children 6-12years of age. The majority (Mean: 50-51%) of Kuwaiti's dietary MeHg exposure comes from the consumption of Hamoor; therefor...
Food additives and contaminants, 2007
The mercury content of 25 samples of fish and seafood products most frequently consumed in Spain was determined. A simple method comprising cold vapour and atomic absorption spectrometry was used to determine separately inorganic and organic mercury. In all samples inorganic mercury content was below 50 microg kg(-1). There was wide variability, among not only the mercury levels of different fish species, but also for different samples of the same species - with the methylmercury content ranging from below 54 to 662 microg kg(-1). The highest mean methylmercury content was found in fresh tuna. Based on an average total fish consumption of 363 g/person week(-1), the methylmercury intake was estimated to be 46.2 microg/person week(-1). Therefore, the mercury intake of Spanish people with a body weight < or = 60 kg is lower than the Joint FAO/WHO Expert Committee on Food Additives (JECFA) provisional tolerable weekly intake (PTWI) of 1.6 microg kg(-1) body weight, but exceeds the US...
Regulatory Toxicology and Pharmacology, 2007
We designed the CORAI (COnsumer Risk Advisory Inquiry) study to observe consumer reactions' after an advisory revealing risk of methylmercury contamination together with benefits of Long-Chain Poly Unsaturated Fatty Acids of the n-3 variety (LC n-3 PUFA). The message was very close to the ones commonly delivered by national food agencies and included recommendations for women of childbearing age and children below 15 years old. Two groups of subjects including consumers at risk were selected. Participants recorded the frequency of their fish consumption detailed by species for them and their family over a one-month period one month before, a month immediately after and 3 month after the advisory. Results were compared between consumers receiving the advisory and controls.
European Journal of Pediatrics, 2009
Methylmercury (MeHg) is a bioaccumulable toxin in the trophic chain and a powerful neurotoxin during fetal and child development. Consumption of contaminated fish and shellfish is a principal environmental source of MeHg exposure. This study was designed to assess the Hg and estimated MeHg intake in vulnerable groups of the Murcia region, a Mediterranean part of Spain, compared with international regulations. A validated food frequency questionnaire was used to assess seafood consumptions in 320 children younger than 10 years, 301 women of childbearing age, and 537 pregnant women. Hg concentrations were measured in the most consumed fish products by cold vapor generation-atomic fluorescence spectrometry.
Regulatory Toxicology and Pharmacology, 2005
This paper presents an updated assessment of exposure in France to methyl mercury through the consumption of fish and fishery products, and proposes several management scenarios which could reduce this exposure through changes to fish contamination levels or fish consumption patterns. The exposure model was applied in line with previous methodological results [Tressou, J., Crépet, A., Bertail, P., Feinberg, M.H., Leblanc J.Ch., 2004a. Probabilistic exposure assessment to food chemicals based on extreme value theory: application to heavy metals from fish and sea products. Food Chem. Toxicol. 42, 1349-1358; Tressou, J., Leblanc, J.Ch., Feinberg, M., Bertail, P., 2004b. Statistical methodology to evaluate food exposure to a contaminant and influence of sanitary limits: application to ochratoxin A. Regul. Toxicol. Pharmacol. 40, 252-263] so as to obtain a realistic estimate of probability and confidence intervals (95% CI) concerning French consumers exposed to levels exceeding the revised fixed provisional tolerable weekly intake (PTWI) for methyl mercury of 1.6 lg/week/kg of body weight, established by the Joint FAO/WHO Expert Committee on Food Additives in 2003. The results showed that young children aged between 3 and 6 years old or 7 and 10 years old, and women of childbearing age were at the risk groups. With respect to these groups and according to the fish consumers patterns (consumers of predatory fish only or consumers of predatory and nonpredatory fish), the results suggested that strategies to diminish MeHg exposure by reducing the amount of predatory fish consumed would be more efficient in significantly decreasing the probability of exceeding the PTWI than the implementation of international standards.
Regulatory Toxicology and Pharmacology, 2013
Mercury (Hg) settlements in the Mediterranean Sea determine a potential toxicological relevance of seafood intakes for coastal populations. To assess this possibility, fish, molluscs, and crustaceans of commercial size of 69 different species were sampled and analyzed for total mercury (Hg TOT ) from georeferenced areas and evaluated for their compliance with the European Union Maximum Residue Limits of 0.5 and 1.0 mg/kg wet weight (ww). Accounting for the weekly estimated seafood intake in the Italian coastal population (mean 469-626 g/person/week) it was then possible to recover threshold contamination values in seafood. Under a Tolerable Weekly Intake of 1.3 lg/kg/bw/week, a threshold seafood contamination <0.10 mg/kg ww has been derived for sensitive groups. A suitable algorithm based on the parallel MeHg and Hg TOT analysis on the most consumed species, helped to refine the uncertainties related to the conservative assumption in seafood all the Hg TOT present is in form of MeHg. This work aims to improve the link between the risk management and risk assessment strategies, with the identification of those fish and seafood species, that, when regularly consumed, could determine or prevent potential Hg TOT /MeHg overintakes in sensitive groups.