Epilepsy in adults with mitochondrial disease: A cohort study (original) (raw)

Annals of neurology, 2015

Abstract

To determine the prevalence and progression of epilepsy in adult patients with mitochondrial disease. We prospectively recruited a cohort of 182 consecutive adult patients attending a specialized mitochondrial disease clinic in Newcastle upon Tyne between Jan 1(st) 2005 and Jan 1(st) 2008. We then followed this cohort over a 7 year period, recording primary outcome measures of occurrence of first seizure, status epilepticus, stroke-like episode, and death. The overall prevalence of epilepsy in the cohort was 23.1%. The mean age of epilepsy onset was 29.4 years. The prevalence varied widely between genotypes, with several genotypes having no cases of epilepsy, a prevalence of 34.9% in the most common genotype (m.3243A>G mutation), and 92.3% in the m.8344A>G mutation. Among the cohort as a whole, focal seizures, with or without progression to bilateral convulsive seizures, was the most common seizure type. Conversely, all of the patients with the m.8344A>G mutation and epilep...

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