Dielectrophoretically Assembled Particles: Feasibility for Optofluidic Systems (original) (raw)
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Dielectrophoresis of micro/nano particles using curved microelectrodes
2012
Dielectrophoresis, the induced motion of polarisable particles in non-homogenous electric field, has been proven as a versatile mechanism to transport, immobilise, sort and characterise micro/nano scale particle in microfluidic platforms. The performance of dielectrophoretic (DEP) systems depend on two parameters: the configuration of microelectrodes designed to produce the DEP force and the operating strategies devised to employ this force in such processes.
Particle Manipulation by Miniaturised Dielectrophoretic Devices
Defence science journal
This paper presents a review of dielectrophoresis (DEP) devices which provide an effective way to manipulate and separate micro- or nano-bioparticles automatically and quickly by polarisation effects in a nonuniform electric field. A detailed review for designs and operation principles of various microfabricated DEP devicesis given and some advantages and disadvantages of current devices are noted to the final system to attain the unprecedented levels of performance.
Optofluidics incorporating actively controlled micro- and nano-particles
Biomicrofluidics, 2012
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Manipulation of Organic and Inorganic Colloidal Particles by Dielectrophoretic Forces
Conference: ASME 2007 International Mechanical Engineering Congress and Exposition, Seattle, Washington, USA, Proc. ASME. 4305X; Volume 11: Micro and Nano Systems, Parts A and B: Paper No. IMECE2007-44093; p. 81-84, 2007
ABSTRACT: Manipulation of the micro and nanoscale objects is of great interest in a variety of engineering and scientific areas. Dielectrophoretic force (DEP) induced technique is predominantly used in the manipulation process in a liquid medium. The phenomenon behind DEP involves the creation of electric forces on particles to generate momentum in non-uniform electric fields, usually resulting from AC electric fields. In the present study, the effects of DEP for the manipulation of organic and inorganic particles at micro and nanoscale is discussed in detail.
Applied Physics Letters, 2010
This manuscript presents an approach for selective manipulation of microparticles using polymer-based optically induced dielectrophoretic ͑ODEP͒ devices. A thin film of a bulk-heterojunction polymer ͓a mixture of regioregular poly͑3-hexylthiophene͒ ͑P3HT͒ and ͓6,6͔-phenyl C61-butyric acid methyl ester ͑PCBM͔͒ is used as a light active layer. The ODEP force is generated by "virtual" electrodes ͑the optical images͒ created from a computer-programmable projector to manipulate polystyrene particles. The magnitude of the ODEP force is found to be dependant on the color of illumination light, due to the variation of the absorption coefficient in the P3HT:PCBM film. A noncontact approach is then demonstrated to separate or collect the polymer particles by shrinking one of the two light rings with different colors and diameters. The development of this promising platform may provide a cost-effective approach for ODEP applications.
Optics Express, 2009
This paper presents a decent polymer material for fabricating optically-induced dielectrophoretic (ODEP) devices, which can manipulate microparticles or cells by using moving light patterns. A thin film of a bulkheterojunction (BHJ) polymer, a mixture of regioregular poly(3hexylthiophene) and [6,6]-phenyl C61-butyric acid methyl ester, is used as a light-activated layer. When illuminated by a projected light beam, the photo-induced charge carriers created by the electron transfer of excitons at a donor/acceptor interface in the BHJ layer, disturbs the uniformlydistributed electric field applied on the ODEP devices. A negative DEP force is then generated by virtual electrodes defined by the optical images from a computer-programmable projector to manipulate microparticles, thus providing a functionalized platform for particle manipulation. The effect of the polymer thickness and composition on the magnitude of the generated DEP force has been extensively investigated. The maximum particle drag velocity and the force applied on 20.0 μm diameter polystyrene beads are measured to be approximately 202.2 μm/s and 38.2 pN, respectively, for a device with a 497.3-nm thick BHJ layer. The lifetime of the developed device is also explored (~5 hours), which is sufficient for applications of disposable ODEP devices. Therefore, the BHJ polymer may provide a promising candidate for future ODEP devices capable of nanoparticle and cell manipulation.
Scientific Reports, 2021
We report a new method to optically manipulate a single dielectric particle along closed-loop polygonal trajectories by crossing a suite of all-fiber Bessel-like beams within a single water droplet. Exploiting optical radiation pressure, this method demonstrates the circulation of a single polystyrene bead in both a triangular and a rectangle geometry enabling the trapped particle to undergo multiple circulations successfully. The crossing of the Bessel-like beams creates polygonal corners where the trapped particles successfully make abrupt turns with acute angles, which is a novel capability in microfluidics. This offers an optofluidic paradigm for particle transport overcoming turbulences in conventional microfluidic chips.
Dielectrophoretic manipulation of particles for use in microfluidic devices
1999
This paper presents a novel device for the dielectrophoretic manipulation of particles and cells. A two-level isotropic etch of a glass substrate was used to create threedimensional ridge-like structures in micrometer-sized channels. Due to the insulating properties of glass, locally patterned regions of nonuniform electric field form near the ridges when a dc field is applied along the channel. The ridges are designed using the method of faceted prisms, such that substantially uniform fields are produced on each side of the faceted interfaces that form each ridge. The dielectrophoretic force that results from the electric field gradient near the ridges is used to affect particle motion parallel to the ridges in the absence of a bulk pressure-driven flow. Trapping and deflection of particles and continuous concentration and separation of Bacillus subtilis from a two-component sample mixture are demonstrated. The flow of B. subtilis is restricted to a selected channel of a planar, multichannel device as a result of negative dielectrophoresis arising from the presence of the insulating ridges when the applied electric field exceeds a threshold of 30 V/mm. Dielectrophoresis has a negligible impact on 200-nm-diameter polystyrene particles under the same conditions. New and improved techniques to characterize and sort microscopic-sized particles and cells are in high demand for a wide range of applications in areas such as biomedical research, clinical diagnostics, and environmental analysis. During sample preparation, trapping of particles facilitates automation of labor-intensive procedures such as filtration, washing, and labeling. During sample analysis, the ability to direct particles selectively down a specific channel to an appropriate assay is useful. Also, during analysis, trapping of particles in specific regions of a chip concentrates the particles, potentially enhancing reaction times, reducing reagent volumes, and improving detection limits. Having the ability to support both sample preparation and analysis, dielectrophoresis (DEP) 1 is an effective way to trap, manipulate, and separate a variety of particles such as ores, 2 clays, 3 bacteria, 4,5 yeast cells, 6,7 large DNA strands, 8 mammalian cells, 9,10 blood cells, 10-12 cancer cells, 12-16 malaria-infected blood cells, 17919 CD 34 stem cells, 20,21 viruses, 22-24 and latex particles. 25-27 DEP is the movement of polarizable and conductive particles toward or away from regions of high electric field intensity in nonuniform electric fields. 27 When particles approach a field gradient, they experience a selective force owing to DEP that is proportional to the particle volume and the difference in complex conductivity of the particle and the fluid. 28 Depending on the relative magnitude of the particle conductivity and that of the fluid, the DEP force can act to drive particles toward regions of either high electric field strength or low electric field strengthstypes
Some Considerations on the Nanoparticles Manipulation in Fluid Media Using Dielectrophoresis
The use of dielectrophoresis (DEP) for controlling the movement of nanoparticles, in view of their selective sorting or filtration from a fluid is analyzed. The dielectrophoretic force produced by the nonuniform electric field acts on the particles in suspension in fluid medium inducing spatial movement depending on the geometry of the electrodes, the frequency of the applied electric field, as well as their dielectric properties or those of the surrounding medium. A theoretical model is proposed and the behavior of a suspension of sub-micronic particles under the action of dielectrophoretic force is numerically investigated.
Tailoring Particles for Optical Trapping and Micromanipulation: An Overview
PIERS Online, 2008
Optical trapping and micromanipulation has developed from an interesting novelty to a powerful and widely used tool, with the capability to move or trap microscopic live biological specimens and measure forces on the order of piconewtons, typical of forces in microbiological systems. Despite this, the range of particles typically trapped or manipulated is quite small, and it is unusual to see applications involving objects other than biological specimens or homogeneous isotropic microspheres, typically polymer or silica. However, particles can be modified or specially fabricated to expand the possible applications of optical tweezers. For example, while non-absorbing homogeneous isotropic spheres cannot be rotated, optically anisotropic spheres can, and can therefore function as microscopic torque sensors, extending the usual translational micromanipulation and force measurement to rotational manipulation and torque sensing. The development of such particles has led to applications in microscale metrology and biophysics, along with potential deployment of optically-driven micromachines in lab-on-a-chip devices. We present an overview of our work on the tailoring of microparticles for versatile optical trapping and micromanipulation. This includes approaches based on controlled chemistry -nanoassembly -and optical microfabrication. Beginning with the production of anisotropic vaterite microspheres, we review some of the applications, and difficulties encountered along the way. Some of these difficulties can be overcome by coating of the vaterite microspheres. We also discuss the use of anti-reflection coating to allow strong trapping of high refractive index particles. The alternative strategy of producing arbitrarily shaped polymer microstructures through two-photon photopolymerization is also discussed. This can be used to produce optically-driven microrotors or structurally anisotropic microspheres to replace vaterites for particular applications.