Histopathological pattern of endometrium in Adenomyosis (original) (raw)
Related papers
Histopathological Association of Adenomyosis with Various Gynaecological Pathologies
Annals of Pathology and Laboratory Medicine, 2020
Objective: To study the histopathological pattern of endometrium and associated pathological conditions in patients presenting with abnormal uterine bleeding due to adenomyosis. Material and Methods: The study was conducted at Maulana Azad Medical College, New Delhi and included 87 patients who underwent hysterectomy and were diagnosed with adenomyosis from Jan 2017 to Dec 2019. These cases were subsequently reviewed for presenting symptoms of adenomyosis and correlated with histomorphological features and associated comorbidities. The quantitative variables were expressed as mean and qualitative variables as percentages. Results and Conclusion: The age of the patients who had adenomyosis ranged from 25 to 65 years, majority were in the age group of 40-50 years. Abnormal uterine bleeding was the most common symptom. The associated histopathological examination reveals pattern of endometrium from proliferative endometrium to endometrial hyperplasia. Estrogen may be a risk factor as it is associated with fibroid and endometrial hyperplasia.
The Correlation of Adenomyosis with Benign Endometrial Lesions in Hysterectomy Samples
Journal of Obstetrics, Gynecology and Cancer Research
Background & Objective: Adenomyosis is a prevalent gynecological disorder among women with no specified causes. It is characterized by nonspecific symptoms, and can present itself as abnormal uterine bleeding, abdominal pain, menstrual disorders, and the like. Its diagnosis is made based on the pathologic histological examination of hysterectomized samples. This study aimed to evaluate the correlation of adenomyosis with other benign endometrial disorders in hysterectomized samples. Materials & Methods: In this paper a total of 413 patients who referred to Rouhani Hospital of Babol, form 2012 to 2017, and underwent a hysterectomy surgery with pathological reports confirming the diagnosis of adenomyosis, were studied. After reviewing the medical records, the patients' data, including their age, weight, number of deliveries, place of residence, and main complaints at the time of referral as well as benign endometrial pathologies correlated with adenomyosis, were examined. Finally, the obtained data were analyzed using statistical tests. Results: The prevalence of adenomyosis in this study was 21.7%. The patients' most common complaints were abnormal uterine bleeding (86.4%), dysmenorrhea (39.2%), abdominal pain (31.2%), dyspareunia (21.1%), mass outflow (15%), and pelvic pain (9.4%). In the current study, the benign pathologies correlated with adenomyosis were leiomyoma (52.5%), uterine polyp (11.9%), adenomyoma (5.1%), and hyperplasia (0.5%). Conclusion: In the present study, the prevalence of adenomyosis was high and abnormal uterine bleeding was the patients' most prevalent complaint. Moreover, leiomyoma had the highest correlation with adenomyosis.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2016
Background: Abnormal uterine bleeding (AUB) is one of the most common presenting complaints encountered by women in reproductive age group. An estimated 60% of visits to a physician's office are from women seeking treatment for menstrual problems. The aim was to assess the burden and prevalence of adenomyosis among hysterectomy specimens for benign causes of AUB in tertiary care institute in Pondicherry. Methods: In this retrospective study, records were retrieved of the patients and pathological specimens of consecutive 184 hysterectomies for benign abnormal uterine bleeding done between May 2007 and May 2008. Patient characteristics were retrieved, and the frequency of adenomyosis in this group was determined. Results: A total of 184 hysterectomies were indicated for benign causes of abnormal uterine bleeding-50 (23.8%) for fibroid, 119 (55.66%,) for adenomyosis, 15 (7.14%) for dysfunctional uterine bleeding, endometrial hyperplasia and others, other than for malignant causes. Age range 33-55 years, mean age was 43.62 years among adenomyosis patients Conclusions: Adenomyosis was diagnosed in 119 (55.66 %) of the benign AUB specimens. Adenomyosis is a frequent cause for failed conservative management culminating in hysterectomy, posing risk to health related quality of life of women with a bearing on emotional, physical, psychosocial, economic issues and family life.
How to evaluate adenomyosis in patients affected by endometriosis?
Minimally invasive surgery, 2014
Objective. The aim of the study is to evaluate adenomyosis in patients undergoing surgery for different type of endometriosis. It is an observational study including women with preoperative ultrasound diagnosis of adenomyosis. Demographic data and symptoms were recorded (age, body mass index, parity, history of previous surgery, dysmenorrhea, dyspareunia, dyschezia, dysuria, and abnormal uterine bleeding). Moreover a particular endometrial shape "question mark sign" linked to the presence of adenomyosis was assessed. Results. From 217 patients with ultrasound diagnosis of adenomyosis, we found 73 with ovarian histological confirmation of endometriosis, 92 with deep infiltrating endometriosis, and 52 patients who underwent surgery for infertility. Women with adenomyosis alone represented the oldest group of patients (37.8 ± 5.18 years, P = 0.02). Deep endometriosis patients were nulliparous more frequently (P < 0.0001), had history of previous surgery (P = 0.004), and co...
Adenomyosis: Is It A Confounder Or An Innocent Companion In Patients With Endometrial Hyperplasia?
2021
Purpose: To evaluate the effect of adenomyosis on the discordance of pathologic findings in patients with endometrial hyperplasia (EH) before hysterectomy.Methods: Two hundred seventeen patients who were diagnosed as having EH via endometrial sampling and underwent hysterectomy within 3 months were included in this retrospective study. The patients’ preoperative and postoperative pathologic findings were compared and discordant results were defined as overdiagnosed and underdiagnosed.Results: The rate of concurrent endometrial carcinoma (EC) among all EH was 22.11%, whereas this rate was 41.4% in EH with atypia. There was no difference between EH subtypes in terms of demographic characteristics and coexisting myometrial lesions. The discordance between preoperative endometrial sampling and final hysterectomy specimen results was evaluated, and patients with underdiagnosis were older (60.5 years, p<0.001), had a higher BMI (30.84 kg/m2, p<0.001), were mostly postmenopausal (p&l...
Adenomyosis among samples from hysterectomy due to abnormal uterine bleeding
2013
BACKGROUND Adenomyosis is one of the most common, yet under diagnosed, underlying cause of abnormal uterine bleeding. We aimed to evaluate the presence of adenomyosis among the patients who presented with abnormal uterine bleeding. METHODS This was a retrospective study carried out on hysterectomy specimens of subjects who presented to the gynaecologist with the complaint of abnormal uterine bleeding not responding to conservative treatment. Excluded are the hysterectomies performed for malignant pelvic neoplasms and hysterectomy following labour for postpartum haemorrhage. RESULTS A total of 861 women underwent hysterectomy out of which 779 w\ere abdominal and 82 vaginal from Jan 2008 to Dec 2012. Adenomyosis was found in 296 of the 861 specimens studied. The most frequent combination of diagnosis was leiomyoma and adenomyosis. Pathologic conditions associated with adenomyosis were: leiomyomas 150 (50.6%), endometrial polyp 16 (5.4%), genital prolapse 12 (4.05%), chronic endometrit...
Is adenomyosis associated with the risk of endometrial cancer?
Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina, 2012
To evaluate an association of adenomyosis with endometrial cancer and to determine the frequency of adenomyosis at hysterectomy specimens. This study was carried out retrospectively on pathologic specimens of hysterectomies. A total of 472 women in the period 2007-2011 enrolled to the study. All pathologies seen in hysterectomy specimens were noted. The frequency of adenomyosis and the accompanying pathologies were determined. These women were categorized into two groups according to the presence of adenomyosis. The incidence of adenomyosis was analyzed together with the endometrial cancer. The incidence of adenomyosis was 20.8% at hysterectomy specimens. There was no statistically significant difference between the mean age of the two groups (p = 0.069). There were 98 cases with adenomyosis and the only pathologic finding was adenomyosis, in 28 (28.5%) cases. The most common accompanying pathologies with adenomyosis were uterine myomas in 51 (52%), uterine polyps in 16 (16.3%) and ...
Is adenomyosis the neglected phenotype of an endomyometrial dysfunction syndrome?
Gynecological Surgery, 2012
Since the dissociation between adenomyoma and endometriosis in the 1920s and the laparoscopic progress in the diagnosis and surgery of endometriosis, the literature has been greatly focused on the disease endometriosis. The study of adenomyosis, on the other hand, has been neglected as the diagnosis remained based on hysterectomy specimens. However, since the introduction of magnetic resonance and sonographic imaging techniques in the 1980s, the myometrial junctional zone has been identified as a third uterine zone and interest in adenomyosis was renewed. This has also been the start for the interest in the role of the myometrial junctional zone dysfunction and adenomyosis in reproductive and obstetrical disorders.
The Professional Medical Journal, 2020
Objectives: To study the clinical features of adenomyosis in hysterectomy specimens which have been proved on histopathology. Study Design: Descriptive study. Setting: Department of Pathology, Quaid-e-Azam Medical College & its Allied Institutes. Period: Jan 2018 to December 2019. Material & Methods: A total specimen of 105 was included in the study and the medical records were examined retrospectively. SPSS v.23.0 was used for data collection and analysis. Results: A total of 105 specimens were included in study. Menorrhagia (55.2%) was most common presenting symptom, most of the patients were multiparous (96.2%) & Dysfunctional uterine bleeding was most common clinical diagnosis (60.0%). Statistical significance was found between different age groups, presenting symptoms & clinical diagnosis. Conclusion: Menorrhagia is most common presenting symptom of adenomyosis, and clinical diagnosis of dysfunctional uterine bleeding was most common. So adenomyosis remain under diagnosed clini...
GJRA. , 2022
Adenomyosis and endometriosis causes similar symptoms and have similar molecular pathogenesis. Aim: This study was done to evaluate the disease burden in south Tamilnadu. And to review its pathogenesis based on various studies published so far to know if we have reached anywhere near targeted therapy. Materials and Methods: It is a cross sectional descriptive study carried on for a year from August 2020_21 in the Department of Pathology, Madurai Medical College on 591 hysterectomy cases for the presence of adenomyosis and endometriosis. Age wise stratication, mean age, age wise incidence and symptoms associated with it were analyzed. To understand pathogenesis, review of concerned articles from PubMed site was done. Results: The incidence of adenomyosis was 15.9% which was higher than that of endometriosis. Peak age incidence of adenomyosis was between 41-45 years and endometriosis was between 25-30 years. Age specic incidence was calculated and it was higher in those who were between 36_40 years. Abnormal uterine bleeding _ Leiomyoma (AUB-L) was the most common symptom associated with adenomyosis and abdominal pain was associated with endometriosis. Kirsten rat sarcoma viral oncogene homolog gene (K RAS) mutation and Nuclear factor kappa light chain enhancer of activated B cell (NFkb) activation associated chronic inammatory status were observed in both. But the dictating pathogenic factor for targeted therapy still eludes. CONCLUSION: The 15.9% incidence of adenomyosis observed in our study is just a tip of an iceberg, as more number of cases remains undiagnosed or those cases which were diagnosed by other modalities are not conrmed by hysterectomy which is the gold standard. Since target therapy for this condition continues to evade, these females continue to suffer with lifelong morbidity and cyclical unproductive and miserable existence.