Isolated Gastric Myeloid Sarcoma: A Case Report and Review of the Literature (original) (raw)
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Isolated Myeloid Sarcoma of the Gastrointestinal Tract
Internal Medicine, 2010
Here, we report the case of a 28-year-old woman with a primary isolated myeloid sarcoma which originated in the gastrointestinal (GI) tract. Two months after intial presentation, bone marrow tests led to a diagnosis of AML. This case is noteworthy because GI tract infiltration with leukemic cells is very rare, and it is even more rare as an occurrence preceding the development of systemic leukemia.
Gastrointestinal Myeloid Sarcoma a Case Presentation and Critical Review of the Literature
Mediterranean Journal of Hematology and Infectious Diseases
Myeloid sarcomas can be detected in up to 30% of acute myeloid leukemia cases or occur de-novo without bone marrow involvement. The most frequent localization of myeloid sarcomas in the abdominal cavity is the small intestine, and gastric presentations are infrequent, frequently misdiagnosed, and a high level of suspicion should exist when the characteristic histomorphology features are present. The current review features a case report with gastric presentation of myeloid sarcoma in a patient with a diagnosis of acute myeloid leukemia with trisomy 8. In addition, a review of the literature of intestinal type myeloid sarcomas shows that less than 15% of these cases have been reported in the stomach. The most common molecular aberrancy detected in intestinal myeloid sarcomas is the fusion protein CBFB-MYH11. Review of several large studies demonstrates that the presence of myeloid sarcoma does not constitute an independent prognostic factor. The therapeutic approach will be tailored ...
A case report of myeloid sarcoma of the gastrointestinal system
Journal of Hematopathology, 2012
Myeloid sarcoma is a tumor mass of myeloblasts or immature myeloid cells occurring in an extramedullary site. The clinical presentation of myeloid sarcoma varies, and many organs or tissues can be involved. Myeloid sarcoma may be found in patients with acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), myeloproliferative neoplasm (MPN), or without any history. Morphologically, these cells may appear like myeloblasts, promyelocytes, or more mature granulocytes. Cytochemical and immunohistochemical stains are extremely important to make the right diagnosis. We report here a case of myeloid sarcoma in an unusual site in an 80-year-old male, without history of AML, MDS, or MPN. The patient presented with perigastric mass and numerous tumor nodules in the liver, mesentery, and omentum. His bone marrow was reactive, without evidence of AML, MDS, or MPN. The tumor masses were proven to be myeloid sarcoma by immunohistochemical stains (positive for CD34, CD68, and lysozyme) and cytogenetic studies.
BMJ case reports, 2018
Myeloid sarcoma (MS) is a rare condition that most commonly occurs in the setting of acute myeloidleukaemia (AML) or other chronic myeloproliferative disorders. It presents as an abnormal growth that can develop anywhere in the human body, and its clinical manifestations are often non-specific.We present the case of a patient admitted to the emergency room with bowel obstruction. After careful clinical assessment, she underwent a right hemicolectomy. After a thorough examination of the surgical pathology specimen, including testing a wide array of immunohistochemical markers, the patient was timely diagnosed with MS, allowing for the implementation of the appropriate treatment to achieve complete remission. This is crucial, since non-leukaemic patients with untreated MS always progress to AML, and have a better prognosis if adequate therapy is implemented early. Our patient is now in the second postoperative year and shows no signs of relapse.
The American Journal of the Medical Sciences, 2009
We present the first known case of the monoblastic type of myeloid sarcoma (also known as extramedullary myeloid tumor, chloroma, and granulocytic sarcoma) with diffuse involvement of the gastrointestinal tract. The patient originally presented with diarrhea and crampy abdominal discomfort. Endoscopically, the disease showed a diffuse inflammatory process mimicking a number of benign conditions, such as inflammatory bowel disease and autoimmune enteropathy. Sequential biopsies of the upper and lower gastrointestinal tract showed a diffuse infiltrate of increasingly atypical cells. The disease progressed to systemic involvement, including widespread lymphadenopathy, splenomegaly, and pulmonary deposits; the patient died 13 months after the development of initial symptoms. The immunohistochemical and histologic profiles of this case are diagnostic of the monoblastic type of myeloid sarcoma.
Primary Myeloid Sarcoma Masquerading as an Obstructing Duodenal Carcinoma
Case Reports in Hematology, 2012
Myeloid Sarcoma (MS), a rare extra hematopoietic carcinoma composed of blast cells, is located primarily in extramedullary sites such as skin, soft tissue, lymph nodes, and bone. MS usually presents in the setting of coexisting acute myeloid leukemia (AML) and myeloproliferative disorders. Gastrointestinal involvement (GI) is extremely rare from nonspecific abdominal symptoms to obstruction. Eight cases of myeloid sarcoma involving the duodenum including the current case have been reported, overall mean age being 40 years (range 17–71) and M : F ratio 7 : 1. The prognosis of patients withde novoMS cases has been reported to be better than those who have a coexisting leukemia. MS is a rare extramedullary tumor, which should be considered in the differential diagnosis of a soft tissue mass involving the duodenum, especially if there is a coexisting hematological disorder.De novocases often progress to AML, and current therapy involves Daunorubicin- and Cytarabine-based chemotherapy. T...
Small-Bowel Myeloid Sarcoma Presenting as A Relapse Case of Acute Myeloid Leukemia
Annals of Pathology and Laboratory Medicine, 2018
Granulocytic sarcoma is an extramedullary tumor of primitive granulocytic cells. It can develop at any anatomic site and is often a prelude to the development of Acute MyelogenousLeukaemia. Granulocytic sarcoma of the small intestine presents with abdominal pain and obstruction. We report a case of a 17 year old boy who presented with epigastric pain. His endoscopy revealed nodular duodenal mucosa and an area of ulcerated exophytic growthin the small bowel. Histopathology and flowcytometery confirmed the diagnosis of granulocytic sarcoma associated with acute myelogenousleukaemia. This case merits interest because of rarity of presentation and thorough clinical and laboratory work up.