Influence of tidal volume and end-expiratory pressure on inspiratory gas distribution and gas exchange during mechanical ventilation in horses positioned in lateral recumbency (original) (raw)

American Journal of Veterinary Research

Abstract

To study effects of intermittent positive-pressure ventilation (IPPV) with large tidal volumes and addition of positive end-expiratory pressure (PEEP) on maldistribution of ventilation in anesthetized horses positioned in lateral recumbency. 6 healthy adult horses. Anesthesia was induced by i.v. infusion of thiopental sodium and guiafenesin and was maintained with supplemental doses of thiopental and i.v. infusion of chloral hydrate. Functional separation of the lungs was achieved, using a tube-in-tube intubation technique. Intermittent positive-pressure ventilation of both lungs with air was done by use of an anesthetic circle system and a ventilator. Data were collected during spontaneous respiration and during IPPV, using increasing tidal volumes with and without PEEP of 10 and 20 cm of H2O. Uneven distribution of inspired gas between the lungs that existed during spontaneous respiration was not altered by IPPV and large tidal volumes. Addition of PEEP caused a significant and re...

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