Genetic testing in maturity onset diabetes of the young (MODY): a new challenge for the diabetic clinic (original) (raw)

Abstract

The identification of five genes that can cause maturity onset diabetes of the young (MODY) means diagnostic and predictive genetic testing is now possible in 80% of MODY families. It is proposed that these recent classifications of diabetes 'genetic disorders of beta cell function' are recognised as separate disorders. Diagnostic genetic tests in those with diabetes will define the subtype, which has specific implications for treatment. In non-diabetic family members predictive tests can be used to test whether the mutated gene has been inherited, indicating >90% chance of developing diabetes.

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