C - reactive protein levels in patients with periodontal disease and normal subjects (original) (raw)
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International journal of applied & basic medical research
Evaluation and comparison of serum C-reactive protein (CRP) levels in subjects with chronic and aggressive periodontitis. Based on the periodontal status, 45 subjects were selected and divided into three groups. Group I - subjects with clinically healthy periodontium, Group II - generalized aggressive periodontitis (GAP), and Group III - chronic periodontitis (CP). Blood samples were collected from subjects for measurement of CRP. Periodontal parameters include plaque index (PI), gingival index, bleeding index (BI), probing pocket depth (PPD), and clinical attachment loss (CAL) were assessed. CRP levels were assessed by means of a commercially available high sensitivity-CRP enzyme immunoassay kit. CRP levels were increased in Group III (6.0671 ± 3.15639 mg/L) and Group II subjects (4.5453 ± 2.88116 mg/L) compared to the Group I (1.0180 ± 0.94069 mg/L). CRP levels showed a positive correlation with all clinical parameters in Group I subjects. BI (r = 0.073), PI (r = 0.120) showed a p...
Correlation Of C -Reactive Protein With The Severity Of Periodontitis
SciDoc Publishers, 2021
Introduction: Although periodontitis is a chronic inflammatory disease, some factors of the acute inflammation phase are involved in this disease among which is the C-Reactive protein (CRP). CRP is one of the diagnostic markers used for the prediction and early detection of periodontal disease. Aim: The main aim was to correlate CRP level with severity of periodontitis. Materials and Methods: The present non-randomized clinical trial was carried out from June 2020 to December 2020 in the Department of Periodontics, Saveetha Dental College and Hospitals, Chennai, India. A total of 21 patients with mild, moderate and severe periodontitis were enrolled and were divided into three groups: Group 1-Mild periodontitis, Group 2-Moderate periodontitis and Group 3-Severe periodontitis with 7 patients in each group. Unstimulated salivary samples were collected and subjected to latex agglutination assay. Result: The mean level of C-Reactive protein level in mild periodontitis patients was 2.25±0.50 mg/dl, 0.56±0.78 mg/dl in moderate periodontitis patients and 4.07±0.67 mg/dl in severe periodontitis patients. We observed a positive correlation that the CRP level increases as the severity of periodontitis increases. Conclusion: The present study suggests that levels of CRP increases with severity of periodontitis. Therefore, CRP can be used as a diagnostic marker for periodontitis.
Rama Univ. J. Dent, 2020
Aims and Objectives: C-reactive protein is an acute-phase-reactant primarily produced by the liver in response to infection or trauma. Recent studies have demonstrated a correlation between periodontitis and elevated CRP levels. This study aims to compare the serum-CRP level in chronic and aggressive periodontitis patients with healthy controls. Materials and Method: A case-control clinical study was conducted with a total of 75 systemically healthy subjects, where 25 subjects were selected in each groups: Group I, Healthy control subjects; Group II, generalized chronic periodontitis patients and Group III, generalized aggressive periodontitis patients. Serum-CRP levels were quantified by using Turbid metric immuno-assay kit at baseline. Kit used was "TURBILYTE-CRP" (Tulip diagnostics, Goa, India). Results: Mean serum CRP levels were significantly higher in both GCP and GAP group as compared to control group at baseline. On comparing the clinical parameters at baseline for GCP & GAP group with control group values, mean score of serum CRP levels for GAP group was statistically significant (P<0.001) in comparison to GCP group, which in turn was statistically significant as compared to control group. Conclusion: The present study indicates a positive correlation between CRP and periodontal disease severity with particular concern in younger individuals, where it could be a possible underlying pathway in the association between periodontal disease and risk for cardiovascular disease in periodontitis patients.
The effect of periodontal treatment on C-reactive protein: A clinical study
Journal of Natural Science, Biology and Medicine, 2013
Background: Chronic periodontitis in amultifactorial inflammatory disease which is caused by various microorganisms. Many studies have found close association between chronic periodontitis and C-reactive protein (CRP). CRPis an inflammatory marker which increases in all inflammatory condition. Aims and Objective: The present clinical study was designed to show the effect of periodontal treatment on the CRP levels of gingival crevicular fluid and to determine the effect of nonsurgical therapy in minimizing the CRP levels in chronic generalized periodontitis. Material and Method: Gingival crevicular fluid was collected using a micro capillary pipette that was hand calibrated at every 1 mm till 10 mm, from selected sites in the subjects on the 1st, 14th and 45th days. Results and Conclusion: Decreased CRP levels of gingival crevicular fluid were observed at the end of the study. There was a 37% reduction in probing pocket depth and 45% gain in clinical attachment level and a reduction of about 57% after 14 days and 90% reduction of CRP levels in gingival crevicular fluid after 45 days. Thus, the results show that the presence of CRP level is more significant in gingival crevicular fluid and confirms the underlying inflammatory component of the disease activity in chronic periodontitis.
Contemporary clinical dentistry, 2014
C-reactive protein (CRP) is an acute-phase reactant and has been proved to be a significant predictor of future cardiovascular events. Recent studies have demonstrated a correlation between periodontitis and elevated CRP levels. However, most of the studies have focused on chronic periodontitis and very few studies are done in patients with aggressive periodontitis. The aim of this study was to determine and compare the relative levels of serum CRP in aggressive and chronic periodontitis patients. A total of 75 systemically healthy subjects were divided into three groups: Group I, nonperiodontitis subjects; group II, chronic generalized periodontitis patients and group III, generalized aggressive periodontitis patients. All participants were subjected to quantitative CRP analysis using enzyme-linked immunosorbent assay. Mean CRP levels were significantly greater in both group II and III as compared to group I and group III having greater level than group II. Furthermore, CRP levels ...
Severe Chronic Periodontitis and C-Reactive Protein Levels
Revista de Saúde Coletiva da UEFS, 2016
This study aims to analyze the relationship between chronic periodontitis and C-reactive protein (CRP), taking certain associated factors into consideration. A cross-sectional study was conducted on a sample of 75 adults of both sexes. After the participants had been interviewed, they underwent physical and dental examinations and blood collection. CRP levels were evaluated by means of nephelometry. A periodontal clinical examination was conducted by trained examiners and the diagnosis of chronic periodontitis was established when at least 30% of the individual’s teeth presented clinical attachment loss ≥ 5 mm. The analysis procedures consisted of descriptive analysis and linear regression. The results showed that there was no statistically significant difference in CRP levels between the groups with and without periodontitis. The median CRP level in the group with periodontitis was 2.3 mg/l (25-75% interquartile range, IQR = 0.74-5.4) and in the group without periodontitis, 1.8 mg/...
Effect of non-surgical periodontal therapy on the levels of C-reactive protein: a pilot study
Revista Odonto Ciencia, 2011
Purpose: C-reactive protein (CRP) is a marker of inflammation that is naturally present in the plasma at levels that may rise due to inflammatory processes, associated with a greater risk of cardiovascular events such as acute myocardial infarction. Periodontal disease is responsible for a host immune-inflammatory response, contributing towards clarifying its association with cardiovascular disease. The aim of this study was to investigate the effect of periodontal therapy on the levels of this inflammatory marker. Methods: The sample consisted of 62 patients of both genders, between the ages of 30 to 60 years, who were referred to dental treatment at the Bahia Foundation for the Development of Sciences, and they were divided into two groups: with and without periodontitis. The clinical descriptors used were the bleeding index, gingival recession, probing depth and clinical attachment level. For CRP analysis, peripheral blood was collected from these individuals and sent to a single clinical analysis laboratory. Results: The group with periodontitis was treated and the results showed that there was a statistically significant difference between the CRP levels before and after periodontal treatment (P<0.05). Conclusion: From the final findings, it may be concluded that non-surgical periodontal therapy showed a tendency to reduce the CRP serum levels.
Journal of Periodontology, 2007
Background: Most studies have evaluated serum C-reactive protein (CRP) levels in chronic periodontitis (CP) patients, and a few investigations have examined gingival crevicular fluid (GCF) CRP levels. The aims of this study were to determine GCF and serum levels of high-sensitivity CRP (HsCRP) in CP patients with or without coronary artery disease (CAD) and to investigate the relationship between the GCF and serum HsCRP levels in CP patients with and without CAD. Methods: Thirty CP patients with angiographically proven CAD, 20 CP patients, and 17 healthy individuals were included in the study. Clinical parameters were recorded, and serum and GCF samples were collected. The level of HsCRP in GCF was assayed by a high-sensitivity enzyme-linked immunosorbent assay. The HsCRP level was assayed in the plasma on a nephelometer. Results: The serum HsCRP levels were significantly higher in CP patients with or without CAD than in the control group, and there was a correlation between serum HsCRP levels and clinical parameters and between serum HsCRP levels and GCF volume. There was no statistically significant difference in GCF HsCRP levels between the groups. There was no correlation between GCF HsCRP levels and clinical parameters, GCF volume, or serum HsCRP levels. Conclusions: Patients with CP and CP + CAD had statistically significant elevations in serum HsCRP levels compared to healthy subjects. However, HsCRP levels of GCF did not differ from those of the control and CP groups or the control and CP + CAD groups. Further studies are needed to clarify the relationship between GCF CRP levels and periodontal diseases.
C-reactive protein as a systemic marker of inflammation in periodontitis
European Journal of Clinical Microbiology & Infectious Diseases, 2011
Periodontitis has been identified as a potential risk factor for systemic pathologies such as cardiovascular disease (CVD). The aims of this investigation were to assess the relationship between periodontitis and systemic inflammatory factor, as well as to discover whether there is a relation to the severity of periodontitis and to the periodontopathogens. Periodontal examinations and serum C-reactive protein (CRP) level measurements were performed in 50 patients with periodontitis. Periodontal health indicators included the gingival bleeding on probing index and periodontal disease status. The patients with moderate periodontitis had low attachment loss and pocket depth <4 mm. The patients with severe periodontitis had high attachment loss and pocket depth >5 mm. The control group comprised 25 volunteers with healthy gingiva, gingival sulcus <2 mm and no attachment loss. The presence of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in subgingival plaque samples was analysed by the polymerase chain reaction (PCR) method. The periodontal parameters and CRP levels were significantly higher in the patients with periodontitis. Patients who had severe periodontitis, with high levels of mean clinical attachment loss, and subjects with moderate periodontitis had higher mean CRP levels. The percentage of subjects with elevated levels of CRP >5 mg/l was greater in the higher clinical attachment loss group compared to the group with lower attachment loss. The presence of P. gingivalis and A. actinomycetemcomitans were also associated with elevated CRP levels and poor periodontal status. Periodontitis and the presence of P. gingivalis are associated with an enhanced inflammatory response expressed by higher CRP levels. The association of periodontitis with CRP levels appears to be a contributing factor for CVD and might be a possible intermediate pathway in this association.