Randomized Trial of Tacrolimus (Prograf) in Combination with Azathioprine or Mychophenolate Mofetil Versus Cyclosporine (Neoral) with Mycophenolate Mofetil After Cadaveric Kidney TRANSPLANTATION1, 2 (original) (raw)

Methods. A randomized three-arm, parallel group, open label, prospective study was performed at 15 North American centers to compare three immunosuppressive regimens: tacrolimus ؉ azathioprine (AZA) versus cyclosporine (Neoral) ؉ mycophenolate mofetil (MMF) versus tacrolimus ؉ MMF. All patients were first cadaveric kidney transplants receiving the same maintenance corticosteroid regimen. Only patients with delayed graft function (32%) received antilymphocyte induction. A total of 223 patients were randomized, transplanted, and followed for 1 year.