Pseudoexfoliation syndrome at Jordan University Hospital (original) (raw)
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Ophthalmology and Therapy
Purpose: To present the clinical profile of patients with pseudoexfoliation (PXF) and describe its association with pseudoexfoliation glaucoma and cataract surgery complications at a university hospital in Jordan. Methods: Electronic chart search was performed among patients aged C 50 years who attended the Jordan University Hospital between January 2015 and March 2018, to identify patients with pseudoexfoliation. Data derived from history and ophthalmic examination regarding laterality of pseudoexfoliation, presence of glaucoma, glaucoma surgery, cataract, cataract surgery, lens instability, and complications of cataract surgery were collected and analyzed. Results: Of 19,753 patient records searched, 962 (477 male and 485 female) had PXF (4.9%). The mean (SD) age was 71.8 (8.1) years. Pseudoexfoliation was unilateral in 539 patients (56.0%). The mean age of patients with clinically bilateral PXF was significantly higher than those with clinically unilateral PXF (p = 0.001). Pseudoexfoliation glaucoma was present in 237 of 962 (25.4%) patients with PXF and was significantly associated with clinically bilateral PXF (p \ 0.001) and male gender (p = 0.001). In 454 (48.9%) patients (638 eyes) who underwent cataract surgery, there was no statistically significant difference in the rate of intraoperative complications between PXF eyes and the fellow eyes of clinically unilateral PXF eyes (p = 0.37), or between patients with clinically unilateral and clinically bilateral PXF (p = 0.78). Conclusion: In this large hospital-based study, the frequency of PXF was 4.9%. Glaucoma was present in one fourth of patients and was significantly associated with clinically bilateral PXF and male gender. Cataract surgery complication rates were not statistically different between PXF and the fellow eyes of clinically unilateral PXF eyes. Surgeons need to be aware of the potential increased risk of intraoperative complications in both groups.
Prevalence of ocular pseudoexfoliation syndrome and associated complications in Riyadh, Saudi Arabia
Saudi Medical Journal, 2015
Objectives: To assess the prevalence of pseudoexfoliation syndrome (PEX), and associated ophthalmic complications among Saudi patients. Methods: The prevalence of PEX and associated ocular co-morbidities were determined among the Saudi patients visiting the Primary Care Clinic of Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia, between January 2009 and January 2010. A total of 1967 patients were examined biomicoscopically by ophthalmologists to determine the presence of PEX and associated ocular complications. Results: Sixty-nine of the 1967 examined patients (3.5%) showed the presence of PEX with no significant gender difference. There was an age dependent increase in the prevalence of PEX after the age of 50 years. Pseudoexfoliation syndrome was associated with higher intraocular pressure, cataract, and poor vision. There was no significant difference in the prevalence of PEX in male and female Saudi patients. Conclusion: Pseudoexfoliation syndrome is an age-related disorder, and its prevalence increases with age. Further larger population based studies are warranted to assess the prevalence of PEX and associated risk factors.
Prevalence of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma in Upper Egypt
BMC Ophthalmology, 2011
Background: Pseudoexfoliation (PXF) is a recognized risk factor for developing cataract, glaucoma and lens dislocation. PXF is also associated with increased risk of complications during cataract surgery due to poor mydriasis and zonular weakness. The aim of this study is to report the prevalence of pseudoexfoliation among Upper Egyptians attending the ophthalmology clinic of Assiut University Hospital. Methodology: A retrospective, chart review study conducted in the period from February 2002 to August 2009. A total of 7738 patients aged 40 years or older attending the general ophthalmic clinics were included in this study. A detailed evaluation including ophthalmic and general history, slit lamp biomicroscopy, intraocular pressure measurement, gonioscopy and dilated eye examination were performed. Patients with pseudoexfoliative material on the anterior lens surface and ⁄ or the pupillary margin in either or both eyes were labeled as having PXF. Results: Out of the 7738 patients included, three hundred twenty (4.14%) subjects had PXF. Mean age of PXF group was 68.15 years (SD 8.16, range 40-92 years). PXF was bilateral in 82.2% of cases. It was significantly associated with cataract, glaucoma and hearing loss. Of the PXF patients, 65% had cataract, 30.3% had glaucoma and 8.1% had hearing loss. Conclusion: Pseudoexfoliation appears to be a common disorder in older individuals in Upper Egypt.
Clinical profile of cataract patients with co-existent pseudoexfoliation syndrome
Innovative Publication, 2017
Introduction: Pseudoexfoliation syndrome (PEX) is a common and clinically important systemic condition characterized by the pathological production and accumulation of an abnormal fibrillar extracellular material in many intraocular and extraocular tissues. Patients with PEX syndrome have a significantly higher risk for a variety of complications during cataract surgery. Aim and Objective: To study the clinical profile of cataract patients with co-existent pseudoexfoliation syndrome. Methodology: 85 patients with Cataract patients diagnosed with pseudoexfoliation on the basis of slit lamp examination. Data includes demographic profile of patient, detailed ophthalmological history and ocular Examination. Visual acuity testing, Slit lamp examination, Gonioscopy, Indirect ophthalmoscopy and Intra Ocular Pressure (IOP) was taken with the help of Schiotz tonometer. Keratometry and A scan was done to calculate IOL power. Results: Males for.med a majority of cases. Majority of the cases were in their sixth decade. In this PEX material was most commonly deposited on Anterior lens capsule 84.7%. Poor pupillary dilatation (<5mm) was seen in as many as 63% cases. 86% eyes had intra-ocular pressure in the range of 14mmHg-21 mm Hg. Discussion and Conclusion: PEX material most commonly deposited on anterior lens capsule. Mixed cataract were more common in pseudoexfoliation syndrome.
Zenodo (CERN European Organization for Nuclear Research), 2021
Aim: To study the clinical profile of pseudoexfoliation (PEX) syndrome and Pseudoexfoliation glaucoma at tertiary care centre in Kashmir. Materials and Methods: A cross sectional study consisting of 100 PEX and 100 PEXG patiens, attending the general ophthalmology clinic of a tertiary care center in kashmir. All patients underwent a complete ophthalmologic evaluation including recording IOP,gonioscopy and Central Corneal Thickness(CCT). Results: The study cohort comprised 200 patients(100 with PEX and 100 with PEXG). There were 145(72.5) males and 55(27.5%) females. The highest number of patients (120 patients) were from the age group between 61 and 70years. 145(72.5%) patients were involved in outdoor activities.153(76.5%) patients had bilateral involvement of pseudoexfoliationand pseudoexfoliative material was present at anterior lens capsule in 175(49.58%) eyes. Nuclear cataract was predominant type of cataract and was present in 188(48.2%)eyes. Mean IOP was 17.26±7.634mmHg in PEX group and 24.39±4.456mmHg in PEXG group. Gonioscopyshowed open angles in 96.5% of eyes and occludable in 3.5% eyes. Mean central corneal thickness was 531.80±19.127μm. Conclusion: The prevalence of PEX is found to increase with age. Patients with PXG had more severity of optic nerve damage at presentation. Therefore a careful assessment for detection of PEX is warranted and regular follow-up of patients is desired to minimize the extent of optic nerve damage.
Vojnosanitetski Pregled, 2014
PURPOSE. The aim of the study was to evaluate several clinical aspects of pseudoexfoliation syndrome (Sy PEX), such as frequency of PEX and pseudoexfoliation glaucoma (PEXG), intraocular pressure (IOP), the type of lens opacity, and the possible relationship of PEX and systemic diseases. METHODS. All 674 cataract patients had a comprehensive eye examination, including slit-lamp biomicroscopy before and after mydriasis, IOP measurement, and fundus examination. The patients were classified into two groups: the PEX and the non-PEX group. RESULTS. The overall prevalence of PEX syndrome was found to be 17.5% (118 patients). The mean age of PEX patients (79.7±6.1 years) was significantly higher when compared with subjects without PEX (73,5±9,1 years) ( p =0.000). The prevalence of PEX syndrome was found to increase with age, from 7.3% in the 7th decade of life to 27% in patients older than 80 years ( p <0.001). The most common cataract type in PEX patients was mature cataract observed ...
PloS one, 2014
To study the clinical correlates of pattern of deposits over the lens in patients with pseudoexfoliation syndrome (PXF) or pseudoexfoliation glaucoma. This retrospective observational study screened 346 patients with PXF seen in glaucoma clinic of a tertiary hospital from 2011-2013. Details like pattern of deposits, location on the lens surface and pupillary abnormalities in slit lamp photographs and their correlation with clinical and demographic variables, were analysed. A total of 84 eyes of 42 patients with bilateral PXF were included for the study. Glaucoma was seen in 30 eyes with baseline IOP of 24+3.8 mm Hg. Comparing the type of deposits, namely classical (n = 39 eyes), radial pigmentary (RP) form (n = 39 eyes) and combined classical and radial pigmentary (CR) forms (n = 6 eyes) of deposits, pupillary ruff atrophy was common in all forms while poor dilatation was rare in the RP type (n = 5 vs n = 25 in classical forms, p < 0.001). Mean deviation (MD) was worse in the cla...
Panacea Journal of Medical Sciences, 2023
Abstract Objective: To study the clinical profile, management and outcomes of pseudoexfoliation (PXF) syndrome with glaucoma in a tertiary eye care hospital. Materials and Methods: This is a prospective hospital based interventional study over a period of two years from January 2020 to December 2022. 300 eyes of 150 cases aged between forty to ninety years, visiting OPD and diagnosed with PXF syndrome with glaucoma were enrolled in the current study. Cases with other causes of glaucoma, ocular trauma or surgery, cases who were lost on follow-up were excluded. Results: In our study, 67% eyes with PXF syndrome were non-glaucomatous and 33% (300 eyes) were glaucomatous which was taken as the study population. PXF syndrome cases having glaucoma showed 43 % of PXF glaucoma, 27% primary open angle glaucoma, 18 % primary angle closure glaucoma and 12 % normal tension glaucoma respectively. Bilateral glaucoma was seen in 83% .Mean Intra ocular Pressure (IOP) of the cases was found to be 18.28 ± 3.48 mmHg. Surgical intervention was done in 20% with surgical complications reported among 16.7 % eyes. Mean IOP after 1 month and 12 month of surgery was 16.8 mmHg and 14.6 mmHg respectively.Greater prevalence rate was found with age greater than 60 yrs, mean being 64 yrs and there was no gender predilection. Conclusions: We observed a greater incidence of PXF syndrome with glaucoma in our region and a positive statistical correlation with increasing age, poor mydriasis and progressive glaucomatous optic neuropathy unresponsive to medical management.Rate of surgical complications was very high.Hence, Ophthalmologists must emphasize on screening and meticulous preoperative examination of PXF to avoid intraoperative complications in these cases. Keywords: Diurnal variation of IOP, Glaucoma, Pseudoexfoliation syndrome, Poor mydriasis
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2022
Introduction: Pseudoexfoliation (PEX) is a systemic disease characterised by the accumulation of dandruff like fluffy deposits of fibrillar granular material. It is the most common cause of secondary open angle glaucoma. Pseudoexfoliation Glaucoma (PXG) is typically associated with rapid visual field loss, greater severity of optic neuropathy and pressure spikes. Aim: To evaluate the clinical characteristic of Pseudoexfoliation Syndrome (PXS) and PXG in the eastern part of Uttar Pradesh. Materials and Methods: This retrospective cross-sectional study was done at Sitapur Eye Hospital, Sitapur, Uttar Pradesh, India. The authors reviewed the medical records database to identify all patients aged 35 years or older with PXG or PXS who attended the outpatient clinic between January 1, 2020 and January 31, 2021. Ethical approval was obtained from the Institutional Review Board at Sitapur Eye Hospital, Sitapur. Continuous variables were calculated by Mann-whitney and student t-test and qual...