The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes (original) (raw)

This review examines the complex interactions between endothelial cells and astrocytes during infectious neurological diseases, specifically focusing on cerebral malaria. It highlights the critical roles of the blood-brain barrier (BBB), the release of various molecules, and new insights into the kynurenine pathway and microparticles in these processes. The mechanisms by which pathogens cross the BBB and the resulting neuroinflammatory responses are also discussed, offering a comprehensive understanding of the interplay between these cell types in the context of infection.