Psychological effects of MDMA (?Ecstasy?) after pretreatment with selective neuroreceptor ligands in healthy volunteers (original) (raw)

2000, Eur Neuropsychopharmacol

AI-generated Abstract

The study investigates the psychological effects of MDMA, especially after pretreatment with selective neuroreceptor ligands in healthy volunteers. Utilizing a double-blind, placebo-controlled design, the research examines how citalopram, haloperidol, and ketanserin influence the effects of MDMA on mood and perception, demonstrating that citalopram significantly reduces positive mood and perceptual changes, while haloperidol and ketanserin exhibit selective reductions in specific psychological dimensions. The findings suggest that MDMA's psychological effects are primarily mediated through serotonin release and receptor interactions.

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